Human serum beta(2)-microglobulin levels: correlation with total serum IgG and placental IgG transfer in HIV-infected and non-HIV infected individuals

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dc.contributor.authorMoraes-Pinto, M. I. de
dc.contributor.authorFarhat, C. K.
dc.contributor.authorFraser, W. D.
dc.contributor.authorHart, C. A.
dc.contributor.authorJohnson, P. M.
dc.contributor.institutionUniv Liverpool
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:30:46Z
dc.date.available2016-01-24T12:30:46Z
dc.date.issued1999-03-01
dc.description.abstractThe acquisition of maternal immunoglobulin G (IgG) is fundamental to the immune defence of the neonate. the receptor responsible for Ige transfer across the human placenta has also been implicated in the maintenance of IgG levels in the circulation. beta(2)-microglobulin is part of the Fc receptor (FcR) that has recently been purified from the human placenta. in HIV infection, increasing serum levels of total IgG and beta(2)-microglobulin are observed as the disease progresses. Herein: we have investigated the correlation between beta(2)-microglobulin and total serum IgG levels in HIV-seropositive mothers and their term neonates (HIV group, n = 37), as well as in HIV-seronegative mothers and their term neonates (control group, n = 50). Serum maternal beta(2)-microglobulin was directly correlated with total serum IgG levels in HIV-infected mothers (r = 0.58; P = 0.0002), but not in healthy HIV-seronegative mothers (r = - 0.20; P = 0.16). Maternal serum beta(2)-microglobulin was also inversely correlated with placental antibody transfer of total IgG in mother-newborn pairs from the HIV group (r = 0.38; P = 0.02), but not from the control group (r = 0.15, P = 0.31). These results seem to indicate that, in HIV infection, elevated serum beta(2)-microglobulin levels could be involved in maintenance of abnormally high total serum IgG concentrations; by interfering with the binding of IgG to Fc receptors at the maternal-fetal interface, they might also reduce IgG transfer. By contrast, in normal non-HIV infected individuals: serum beta(2)-microglobulin levels do not appear implicated in regulation of these two phenomena. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.en
dc.description.affiliationUniv Liverpool, Dept Immunol, Liverpool L69 3BX, Merseyside, England
dc.description.affiliationUniversidade Federal de São Paulo, Dept Paediat, Div Infect Dis, São Paulo, Brazil
dc.description.affiliationUniv Liverpool, Dept Med Microbiol, Liverpool L69 3BX, Merseyside, England
dc.description.affiliationUniv Liverpool, Dept Clin Chem, Liverpool L69 3BX, Merseyside, England
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Paediat, Div Infect Dis, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent167-174
dc.identifierhttp://dx.doi.org/10.1016/S0165-0378(98)00083-7
dc.identifier.citationJournal of Reproductive Immunology. Clare: Elsevier Sci Ireland Ltd, v. 42, n. 2, p. 167-174, 1999.
dc.identifier.doi10.1016/S0165-0378(98)00083-7
dc.identifier.issn0165-0378
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/26041
dc.identifier.wosWOS:000079456900007
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Reproductive Immunology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectplacental IgG transferen
dc.subjectIgG catabolismen
dc.subjectbeta(2)-microglobulinen
dc.subjectHIV infectionen
dc.subjectFc receptoren
dc.titleHuman serum beta(2)-microglobulin levels: correlation with total serum IgG and placental IgG transfer in HIV-infected and non-HIV infected individualsen
dc.typeinfo:eu-repo/semantics/article
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