Spectral-domain optical coherence tomography imaging of drusenoid pigment epithelial detachments

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dc.contributor.authorGarcia Filho, Carlos Alexandre de Amorim [UNIFESP]
dc.contributor.authorYehoshua, Zohar
dc.contributor.authorGregori, Giovanni
dc.contributor.authorFarah, Michel Eid [UNIFESP]
dc.contributor.authorFeuer, William
dc.contributor.authorRosenfeld, Philip J.
dc.contributor.institutionUniv Miami
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-18T11:35:38Z
dc.date.available2018-06-18T11:35:38Z
dc.date.issued2013-09-01
dc.description.abstractPurpose: To evaluate drusenoid retinal pigment epithelial detachments (DPED) secondary to age-related macular degeneration (AMD) using spectral-domain optical coherence tomography imaging.Methods: In this prospective natural history study, eyes from patients with the diagnosis of nonexudative AMD and DPEDs were followed for at least 6 months. Eyes were scanned using the Cirrus spectral-domain optical coherence tomography instrument and the 200 x 200 A-scan raster pattern. A custom software was used to quantify volumetric changes in DPEDs and to detect the evolution and formation of geographic atrophy and choroidal neovascularization. Changes in DPED area and volume and development of the advanced forms of AMD were the main outcome.Results: Of the 130 patients (186 eyes) with nonadvanced AMD, 11 patients (16 eyes) presented with DPEDs during the study. Mean follow-up was 18.5 months. Most DPEDs had an area exceeding 1 disk area (14 of 16 eyes) based on color fundus images with a mean area of 4.19 mm(2) (SD = 1.35) measured by spectral-domain optical coherence tomography. The mean volume at the time the DPED was diagnosed was 0.48 mm(3) (SD = 0.28). Four different patterns of progression were observed: DPEDs remained unchanged in 8 of 16 eyes (50%), DPEDs tended to increase in volume before progressing to geographic atrophy in 5 eyes (31.25%) and choroidal neovascularization in 2 eyes (12.5%), and a DPED decreased by more than 50% without progressing to geographic atrophy or choroidal neovascularization in 1 eye (6.25%).Conclusion: Spectral-domain optical coherence tomography imaging is able to detect subtle changes in the area and volume of DPEDs. Quantitative spectral-domain optical coherence tomography imaging of DPEDs is useful for identifying the natural history of disease progression and as a clinical tool for monitoring eyes with AMD in clinical trials.en
dc.description.affiliationUniv Miami, Miller Sch Med, Bascom Palmer Eye Inst, Dept Ophthalmol, Miami, FL 33136 USA
dc.description.affiliationUniv Fed Sao Paulo, Dept Ophthalmol, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Ophthalmol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCarl Zeiss Meditec, Inc, Dublin, CA
dc.description.sponsorshipResearch to Prevent Blindness, Inc
dc.description.sponsorshipNEI core center
dc.description.sponsorshipDepartment of Defense (DOD)
dc.description.sponsorshipJerome A. Yavitz Charitable Foundation
dc.description.sponsorshipMacula Vision Research Foundation
dc.description.sponsorshipFeig Family Foundation
dc.description.sponsorshipGemcon Family Foundation
dc.description.sponsorshipCarl and Lily Pforzheimer Foundation
dc.description.sponsorshipEmma Clyde Hodge Memorial Foundation
dc.description.sponsorshipCarl Zeiss Meditec, Inc.
dc.description.sponsorshipIDNEI core center: P30 EY014801
dc.description.sponsorshipIDDepartment of Defense (DOD): W81XWH-09-1-0675
dc.format.extent1558-1566
dc.identifierhttp://dx.doi.org/10.1097/IAE.0b013e318285cbd2
dc.identifier.citationRetina-the Journal Of Retinal And Vitreous Diseases. Philadelphia: Lippincott Williams & Wilkins, v. 33, n. 8, p. 1558-1566, 2013.
dc.identifier.doi10.1097/IAE.0b013e318285cbd2
dc.identifier.issn0275-004X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/45222
dc.identifier.wosWOS:000330233200010
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofRetina-the Journal Of Retinal And Vitreous Diseases
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectspectral-domain optical coherence tomographyen
dc.subjectSD-OCTen
dc.subjectage-related macular degenerationen
dc.subjectAMDen
dc.subjectretinal pigmented epithelial detachmenten
dc.subjectPEDen
dc.subjectdrusenoid PEDen
dc.titleSpectral-domain optical coherence tomography imaging of drusenoid pigment epithelial detachmentsen
dc.typeinfo:eu-repo/semantics/article
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