Effects of prenatal and lactation nicotine exposure on rat testicular interstitial tissue

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dc.contributor.authorPaccola, Camila Cicconi [UNIFESP]
dc.contributor.authorNeves, F. M. O. [UNIFESP]
dc.contributor.authorCipriano, I. [UNIFESP]
dc.contributor.authorStumpp, Taiza [UNIFESP]
dc.contributor.authorMiraglia, Sandra Maria [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:35:20Z
dc.date.available2016-01-24T14:35:20Z
dc.date.issued2014-03-01
dc.description.abstractNicotine is largely consumed as a component of cigarettes. It induces apoptosis, interferes with endocrine function by changing the sex hormones secretion and leads to male infertility. Testosterone is produced from cholesterol by Leydig cells (LC), with the participation of testicular macrophages (MO). Thus, to investigate whether nicotine administration to pregnant and lactating rats changes cholesterol and sexual hormone levels and LC and MO populations of offspring, female rats received nicotine (2mg/kg/day) through osmotic minipumps from the first day of pregnancy up to the end of weaning. At 1, 30, 60 and 90days post-partum (dpp) the plasma cholesterol and testosterone levels were obtained, as well as the biometric, histopathological and stereological testicular parameters. Nicotine reduced the body weight, cholesterol levels and lipid droplet number in foetal LC at 1dpp. the number of apoptotic LC did not change in the offspring of nicotine group at any age studied. No alterations in the numerical densities of MO and LC occurred at 60 and 90dpp. Hypertrophy of mature LC and increase in cholesterol and testosterone levels were noted at 90dpp. in conclusion, nicotine when administered to rats throughout pregnancy and lactation induces morphofunctional alterations of foetal and mature LC and affects cholesterol and testosterone levels.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Morphol & Genet, Dev Biol Lab, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Morphol & Genet, Dev Biol Lab, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIDFAPESP: 2009/07855-6
dc.format.extent175-185
dc.identifierhttp://dx.doi.org/10.1111/j.2047-2927.2013.00168.x
dc.identifier.citationAndrology. Hoboken: Wiley-Blackwell, v. 2, n. 2, p. 175-185, 2014.
dc.identifier.doi10.1111/j.2047-2927.2013.00168.x
dc.identifier.issn2047-2919
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/37461
dc.identifier.wosWOS:000331696100004
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofAndrology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectLeydig cellen
dc.subjectnicotineen
dc.subjectraten
dc.subjecttestisen
dc.subjecttesticular macrophageen
dc.titleEffects of prenatal and lactation nicotine exposure on rat testicular interstitial tissueen
dc.typeinfo:eu-repo/semantics/article
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