Quality of life as a prognostic marker in pulmonary arterial hypertension

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dc.contributor.authorFernandes, Caio J. C. S.
dc.contributor.authorMartins, Barbara C. S.
dc.contributor.authorJardim, Carlos V. P.
dc.contributor.authorCiconelli, Rozana M. [UNIFESP]
dc.contributor.authorMorinaga, Luciana K.
dc.contributor.authorBreda, Ana Paula
dc.contributor.authorHoette, Susana
dc.contributor.authorSouza, Rogerio
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:37:44Z
dc.date.available2016-01-24T14:37:44Z
dc.date.issued2014-08-30
dc.description.abstractBackground: Improvement in quality of life together with better survival are the ultimate goals in the treatment of pulmonary arterial hypertension (PAH) patients. the objective of this study was to evaluate the health-related quality of life (HRQL) of pulmonary arterial hypertension (PAH) patients with the SF-36 generic questionnaire and to identify the prognostic implication of this assessment.Methods: Fifty-four consecutive newly diagnosed PAH patients (WHO classification group I) in a single PAH reference center were included. Patients were evaluated at baseline for clinical and hemodynamic parameters, and they subsequently received first-line therapy with either an endothelin receptor antagonist or a phosphodiesterase-5 inhibitor. After 16 weeks of specific PAH therapy, all patients were re-evaluated using a 6MWT and a SF 36 questionnaire, and then they were followed up for at least 36 months.Results: After treatment, the patients demonstrated an improved 6MWT (414 +/- 124 m vs. 440 +/- 113 m, p = 0.001). Specific PAH therapy also improved the HRQL scores.Patients with a baseline Physical Component Score (PCS) higher than 32 had a better survival rate than those who had a score under 32 (p = 0.04). Similarly, patients with a PCS of at least a 38 after the 16 week therapy period had a better survival rate when compared with those who did not achieve this value (p = 0.016). Unlike the absolute PCS values, the post-treatment PCS variability was unable to predict better survival rates (p = 0.58).Conclusions: Our findings suggest that HRQL is associated with prognosis in PAH. Furthermore, achieving pre-determined PCS scores might represent a specific goal to be reached in treatment-to-target strategies.en
dc.description.affiliationUniv São Paulo, Sch Med, Pulm Dept, Inst Heart, BR-05403000 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Rheumatol Dept, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Rheumatol Dept, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent6
dc.identifierhttp://dx.doi.org/10.1186/s12955-014-0130-3
dc.identifier.citationHealth and Quality of Life Outcomes. London: Biomed Central Ltd, v. 12, 6 p., 2014.
dc.identifier.doi10.1186/s12955-014-0130-3
dc.identifier.fileWOS000342017900001.pdf
dc.identifier.issn1477-7525
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/38109
dc.identifier.wosWOS:000342017900001
dc.language.isoeng
dc.publisherBiomed Central Ltd
dc.relation.ispartofHealth and Quality of Life Outcomes
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectQuality of lifeen
dc.subjectPulmonary arterial hypertensionen
dc.subjectSurvivalen
dc.subjectPrognosisen
dc.subjectTreatmenten
dc.titleQuality of life as a prognostic marker in pulmonary arterial hypertensionen
dc.typeinfo:eu-repo/semantics/article
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