Tendências de publicações relacionadas à doença de alzheimer e exossomos: uma análise bibliométrica
Data
2021-07-08
Autores
Toledo, Phelipe Bagesterio Martins 
Orientadores
Sinigaglia, Rita de Cássia
Tipo
Dissertação de mestrado
Título da Revista
ISSN da Revista
Título de Volume
Resumo
Objetivo: analisar as interações entre publicações que estudam a relação entre a
doença de Alzheimer e os exossomos através da bibliometria, a fim de identificar o
impacto desses temas na comunidade cientifica e quais são os temas mais relevantes
de pesquisa atualmente para projetos futuros.
Resultados: Os artigos levantados levaram a criação de uma rede de informações
dos últimos quinze anos, possibilitando a identificação dos temas abordados
atualmente, como a identificação e caracterização de microRNAs, a propagação de
proteínas beta-amiloide e TAU hipersoforilada através de exossomos e sua
contribuição para a evolução do quadro clínico da doença de Alzheimer. Conclusão:
O levantamento bibliométrico possibilitou compreender a relação dos exossomos com
a doença de Alzheimer, e diversas moléculas envolvidas desde o surgimento da
doença até a sua evolução para estágios mais tardios. Desta forma, projetos de
pesquisas envolvendo a análise epigenética da relação da doença de Alzheimer com
os exossomos, como os microRNAs e análise de metiloma auxiliarão no entendimento
da etiologia e evolução da doença.
Objective: Analyze the interactions between publications studying the relationship between Alzheimer's disease and exosomes through bibliometric analysis to identify the impact of these themes on the scientific community. Additionally, we intended to identify the most relevant research topics currently for future projects. Results: The articles led to the creation of an information network over the last fifteen years, enabling the identification of current topics, such as the identification and characterization of microRNAs, the propagation of beta-amyloid and hyperphosphorylated TAU proteins through exosomes and their contribution to the evolution of the clinical landscape of Alzheimer's disease. Conclusion: The bibliometric made it possible to understand the relationship of exosomes with Alzheimer's disease, and various molecules involved from the onset of the disease to its evolution to later stages. Thus, research projects involving the epigenetic analysis of the relationship between Alzheimer's disease and exosomes, such as microRNAs and methylome analysis, will help to understand the etiology and evolution of the disease.
Objective: Analyze the interactions between publications studying the relationship between Alzheimer's disease and exosomes through bibliometric analysis to identify the impact of these themes on the scientific community. Additionally, we intended to identify the most relevant research topics currently for future projects. Results: The articles led to the creation of an information network over the last fifteen years, enabling the identification of current topics, such as the identification and characterization of microRNAs, the propagation of beta-amyloid and hyperphosphorylated TAU proteins through exosomes and their contribution to the evolution of the clinical landscape of Alzheimer's disease. Conclusion: The bibliometric made it possible to understand the relationship of exosomes with Alzheimer's disease, and various molecules involved from the onset of the disease to its evolution to later stages. Thus, research projects involving the epigenetic analysis of the relationship between Alzheimer's disease and exosomes, such as microRNAs and methylome analysis, will help to understand the etiology and evolution of the disease.