Evaluation of antimicrobial and antitumoral activity of Garcinia mangostana L. (mangosteen) grown in Southeast Brazil

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dc.contributor.authorCunha, Bruna Lais Almeida
dc.contributor.authorFrança, Jerônimo Pereira de [UNIFESP]
dc.contributor.authorMoraes, Andrea Aparecida Fátima Souza [UNIFESP]
dc.contributor.authorChaves, Alba Lucilvânia Fonseca
dc.contributor.authorGaiba, Silvana
dc.contributor.authorFontana, Renato
dc.contributor.authorSacramento, Celio Kersul do
dc.contributor.authorFerreira, Lydia Masako [UNIFESP]
dc.contributor.authorFrança, Lucimar Pereira de
dc.contributor.institutionUniversidade Estadual de Santa Cruz Department of Biological Sciences
dc.contributor.institutionUniversidade Estadual de Santa Cruz Departament of Agricultural and Environmental Sciences
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2015-06-14T13:46:49Z
dc.date.available2015-06-14T13:46:49Z
dc.date.issued2014-01-01
dc.description.abstractPURPOSE:To characterize the anatomy of the fruit and leaf and the presence of phytocompounds. To evaluate the antitumor and antimicrobial activity of ethanolic extract of Garcinia mangostana L. (mangosteen) cultivated in southeastern Brazil.METHODS:Anatomical characterization and histochemical reactions were performed for structural identification and the presence of phytocompounds. Preparation of ethanolic extract of the fruit, leaf and resin of mangosteen. Culture B16-F10 melanoma cells for treatment with mangosteen ethanolic extract to determine cell viability by MTT and genotoxic effect by comet assay. Evaluation by antimicrobial activity against Staphylococcus aureus and Escherichia coli by agar diffusion test and by determination of Minimum Inhibitory Concentration (MIC).RESULTS:Our results showed many secretory canals in resin fruit and leaf; identifying lipids, starch, lignin and phenolic compounds. The leaf extract induced genotoxicity and apoptosis in B16-F10 cells, since the fragmentation of DNA in the comet assay. The ethanolic extract of mangosteen obtained in the resin, leaf and fruit showed antimicrobial activity against Staphylococcus aureus and Escherichia coli with a MIC at 0.1 mg/mL.CONCLUSION: In conclusion, we have demonstrated both antimicrobial and antitumor activity of ethanol extract of mangosteen emphasizing its therapeutic potential in infectious diseases and in cancer, such as melanoma.en
dc.description.affiliationUniversidade Estadual de Santa Cruz Department of Biological Sciences
dc.description.affiliationUniversidade Estadual de Santa Cruz Departament of Agricultural and Environmental Sciences
dc.description.affiliationUNIFESP
dc.description.affiliationUnifespUNIFESP
dc.description.sourceSciELO
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipBahia Research Foundation (FAPESB)
dc.format.extent21-28
dc.identifierhttp://dx.doi.org/10.1590/S0102-86502014001400005
dc.identifier.citationActa Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 29, p. 21-28, 2014.
dc.identifier.doi10.1590/S0102-86502014001400005
dc.identifier.fileS0102-86502014001400006.pdf
dc.identifier.issn0102-8650
dc.identifier.scieloS0102-86502014001400006
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/8139
dc.identifier.wosWOS:000342065300006
dc.language.isoeng
dc.publisherSociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.relation.ispartofActa Cirurgica Brasileira
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectGarcinia mangostana L.en
dc.subjectDrug Screening Assays, Antitumoren
dc.subjectAnti-Infective Agentsen
dc.subjectAntimicrobialen
dc.titleEvaluation of antimicrobial and antitumoral activity of Garcinia mangostana L. (mangosteen) grown in Southeast Brazilen
dc.typeinfo:eu-repo/semantics/article
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