Neuromyelitis optica spectrum disorders: beyond longitudinally extensive transverse myelitis

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dc.contributor.authorLemos, M. D. [UNIFESP]
dc.contributor.authorCarvalho, G. B. S. [UNIFESP]
dc.contributor.authorCarvalho, R. S. [UNIFESP]
dc.contributor.authorBichuetti, D. B. [UNIFESP]
dc.contributor.authorOliveira, E. M. L. de [UNIFESP]
dc.contributor.authorAbdala, Nitamar [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:40:33Z
dc.date.available2016-01-24T14:40:33Z
dc.date.issued2015-06-01
dc.description.abstractAIM: To describe the neuroradiological features and their prevalence in patients with neuromyelitis optica (NMO).MATERIALS and METHODS: Two neuroradiologists independently reviewed 35 spinal cord and 37 brain MRI studies from patients with NMO. the examinations were analysed for the presence of lesion, topography, enhancement, and brain lesions suggestive of multiple sclerosis and/or NMO.RESULTS: Seventy percent of the spinal cord lesions involved over three or more vertebral segments. Seventy-eight percent of brain scans were abnormal, and the most prevalent findings were non-specific foci of T2 hyperintensities in the cerebral white matter (55%) and brainstem lesions (52%). One patient had lesions disseminated in space compatible with multiple sclerosis according to 2010 revised McDonald criteria. Brain lesions suggestive of NMO occurred at least once in 17 (59%) patients.CONCLUSION: Spinal cord lesions were often longitudinally extensive and brain lesions-were common, with the majority of patients having at least one distinctive NMO lesion. (C) 2015 the Royal College of Radiologists. Published by Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Diagnost Imagem, BR-04024002 São Paulo, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Disciplina Neurol, BR-04024002 São Paulo, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Diagnost Imagem, BR-04024002 São Paulo, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Disciplina Neurol, BR-04024002 São Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipBayer Health Care
dc.description.sponsorshipMerck Serono
dc.description.sponsorshipTEVA
dc.format.extent630-637
dc.identifierhttp://dx.doi.org/10.1016/j.crad.2015.02.016
dc.identifier.citationClinical Radiology. London: W B Saunders Co Ltd, v. 70, n. 6, p. 630-637, 2015.
dc.identifier.doi10.1016/j.crad.2015.02.016
dc.identifier.issn0009-9260
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/39124
dc.identifier.wosWOS:000355062200010
dc.language.isoeng
dc.publisherW B Saunders Co Ltd
dc.relation.ispartofClinical Radiology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.titleNeuromyelitis optica spectrum disorders: beyond longitudinally extensive transverse myelitisen
dc.typeinfo:eu-repo/semantics/article
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