Sarcomatoid differentiation in renal cell carcinoma: prognostic implications

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dc.contributor.authorDall'Oglio, Marcos Francisco [UNIFESP]
dc.contributor.authorLieberknecht, Marco [UNIFESP]
dc.contributor.authorGouveia, Valter [UNIFESP]
dc.contributor.authorSant'anna, Alexandre C. [UNIFESP]
dc.contributor.authorLeite, Kátia Ramos Moreira [UNIFESP]
dc.contributor.authorSrougi, Miguel [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2015-06-14T13:31:26Z
dc.date.available2015-06-14T13:31:26Z
dc.date.issued2005-02-01
dc.description.abstractINTRODUCTION: Renal cell carcinoma with sarcomatoid differentiation is a tumor with aggressive behavior that is poorly responsive to immunotherapy. The objective of this study is to report our experience in the treatment of 15 patients with this tumor. MATERIALS AND METHODS: We retrospectively analyzed 15 consecutive cases of renal cell carcinoma with sarcomatoid differentiation diagnosed between 1991 and 2003. The clinical presentation and the pathological stage were assessed, as were the tumor's pathological features, use of adjuvant immunotherapy and survival. The study's primary end-point was to assess survival of these individuals. RESULTS: The sample included 8 women and 7 men with mean age of 63 years (44 - 80); follow-up ranged from 1 to 100 months (mean 34). Upon presentation, 87% were symptomatic and 4 individuals had metastatic disease. Mean tumor size was 9.5 cm (4 - 24) with the following pathological stages: 7% pT1, 7% pT2, 33% pT3, and 53% pT4. The pathological features showed high-grade tumors with tumoral necrosis in 87% of the lesions and 80% of intratumoral microvascular invasion. Disease-free and cancer-specific survival rates were 40 and 46% respectively, with 2 cases responding to adjuvant immunotherapy. CONCLUSIONS: Patients with sarcomatoid tumors of the kidney have a low life expectancy, and sometimes surgical resection associated with immunotherapy can lead to a long-lasting therapeutic response.en
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina (EPM) Division of Urology
dc.description.affiliationUnifespUNIFESP, EPM, Division of Urology
dc.description.sourceSciELO
dc.format.extent10-16
dc.identifierhttp://dx.doi.org/10.1590/S1677-55382005000100003
dc.identifier.citationInternational braz j urol. Sociedade Brasileira de Urologia, v. 31, n. 1, p. 10-16, 2005.
dc.identifier.doi10.1590/S1677-55382005000100003
dc.identifier.fileS1677-55382005000100003.pdf
dc.identifier.issn1677-5538
dc.identifier.scieloS1677-55382005000100003
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/2395
dc.language.isoeng
dc.publisherSociedade Brasileira de Urologia
dc.relation.ispartofInternational braz j urol
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectkidney neoplasmsen
dc.subjectcarcinomaen
dc.subjectrenal cellen
dc.subjectneoplasms metastasisen
dc.titleSarcomatoid differentiation in renal cell carcinoma: prognostic implicationsen
dc.typeinfo:eu-repo/semantics/article
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