TESTOSTERONE CONTROL of END-PLATE and NON-END-PLATE ACETYLCHOLINESTERASE in the RAT LEVATOR ANI MUSCLE

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dc.contributor.authorGodinho, R. O.
dc.contributor.authorSouccar, C.
dc.contributor.authorLapa, A. J.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T11:40:18Z
dc.date.available2016-01-24T11:40:18Z
dc.date.issued1994-06-01
dc.description.abstractThe time course of effects of castration (5-60 days) and testosterone treatment (15-60 days) of adult male rats were examined on the endplate (+EP) and non-endplate (-EP) acetylcholinesterase (AChE) of the androgen-dependent levator ani (LA) muscle. the thiocholine method was used to determine the enzyme activity. Castration caused LA muscle atrophy within 5 days but reduced the -EP and +EP AChE after 10 and 20 days, respectively. Following 30 days castration -EP and +EP AChE reached respectively 41% and 35% of control activity. Testosterone retrieval restored the control values of both muscle weight and total AChE after 15 and 60 days, respectively. Recovery of the +EP AChE preceded that of -EP AChE by 30 days. the results showed that in the rat LA muscle, +EP and -EP AChE depend on a continuous testosterone regulation that predominates at +EP region spreading thereafter to -EP region. Those data suggest a hormone regulation of AChE exerted indirectly through the synthesis and release of neurotrophic substances.en
dc.description.affiliationESCOLA PAULISTA MED,DEPT PHARMACOL,DIV CELLULAR PHARMACOL,BR-04044020 São Paulo,BRAZIL
dc.description.affiliationUnifespESCOLA PAULISTA MED,DEPT PHARMACOL,DIV CELLULAR PHARMACOL,BR-04044020 São Paulo,BRAZIL
dc.description.sourceWeb of Science
dc.format.extent657-663
dc.identifierhttp://dx.doi.org/10.1007/BF00967703
dc.identifier.citationNeurochemical Research. New York: Plenum Publ Corp, v. 19, n. 6, p. 657-663, 1994.
dc.identifier.doi10.1007/BF00967703
dc.identifier.issn0364-3190
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/25411
dc.identifier.wosWOS:A1994NK71000003
dc.language.isoeng
dc.publisherPlenum Publ Corp
dc.relation.ispartofNeurochemical Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectACETYLCHOLINESTERASEen
dc.subjectLEVATOR ANI MUSCLEen
dc.subjectTESTOSTERONEen
dc.subjectSKELETAL MUSCLEen
dc.subjectNEUROMUSCULAR JUNCTIONen
dc.titleTESTOSTERONE CONTROL of END-PLATE and NON-END-PLATE ACETYLCHOLINESTERASE in the RAT LEVATOR ANI MUSCLEen
dc.typeinfo:eu-repo/semantics/article
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