Angiotensinogen and angiotensin converting enzyme gene polymorphisms and the risk of bipolar affective disorder in humans

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dc.contributor.authorMeira-Lima, IV
dc.contributor.authorPereira, A. C.
dc.contributor.authorMota, GFA
dc.contributor.authorKrieger, J. E.
dc.contributor.authorVallada, H.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:31:11Z
dc.date.available2016-01-24T12:31:11Z
dc.date.issued2000-10-27
dc.description.abstractA possible participation of the renin-angiotensin system (RAS) components with mood disturbances has been suggested in both animal and pharmacological models. in this cross-sectional study, we examined the association between functional polymorphisms in the angiotensin converting enzyme (ACE) and angiotensinogen (AGI) genes in 115 bipolar affective disorder (BPAD) patients and 323 healthy control subjects. the ACE I/D variant did not show any difference in allelic frequencies and genotypic distribution between the groups. in contrast, when studying the AGT M235T polymorphism we found that the M allele was more frequently observed in BPAD patients than in controls (chi (2) = 6.766, d.f. = 1, P = 0.009). Using multivariate logistic models the strongest odds ratio resulted from a dominant genetic model (OR = 3.0; CI (95%) 1.7-5.3] Our data suggest an association between the AGT M235 genotype and increased susceptibility for BPAD in these Brazilian patients. These findings are consistent with the hypothesis that the RAS system plays a role in regulating the mood (C) 2000 Published by Elsevier Science Ireland Ltd.en
dc.description.affiliationUniv São Paulo, Sch Med, Inst Psychiat, Lab Neurosci LIM 27, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Sch Med, Dept Med, Lab Genet & Mol Cardiol LIM 13,Heart Inst InCor, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychiat, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychiat, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent103-106
dc.identifierhttp://dx.doi.org/10.1016/S0304-3940(00)01512-3
dc.identifier.citationNeuroscience Letters. Clare: Elsevier Sci Ireland Ltd, v. 293, n. 2, p. 103-106, 2000.
dc.identifier.doi10.1016/S0304-3940(00)01512-3
dc.identifier.issn0304-3940
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/26399
dc.identifier.wosWOS:000090010400006
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofNeuroscience Letters
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectaffective disorderen
dc.subjectrenin-angiotensin systemen
dc.subjectgeneticen
dc.subjectassociation studyen
dc.titleAngiotensinogen and angiotensin converting enzyme gene polymorphisms and the risk of bipolar affective disorder in humansen
dc.typeinfo:eu-repo/semantics/article
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