High Rate of Viral Identification and Coinfections in Infants with Acute Bronchiolitis

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dc.contributor.authorNascimento, Milena Siciliano [UNIFESP]
dc.contributor.authorSouza, Andrea Vieira de [UNIFESP]
dc.contributor.authorFerreira, Adriana Vada de Souza
dc.contributor.authorRodrigues, Joaquim Carlos [UNIFESP]
dc.contributor.authorAbramovici, Sulim
dc.contributor.authorSilva Filho, Luiz Vicente Ferreira da
dc.contributor.institutionHosp Israelita Albert Einstein
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:59:02Z
dc.date.available2016-01-24T13:59:02Z
dc.date.issued2010-01-01
dc.description.abstractOBJECTIVES: To determine the viruses and risk factors associated with hospital and intensive care unit (ICU) admissions in infants with acute bronchiolitis.INTRODUCTION: Bronchiolitis is a major cause of morbidity in infants. Widespread use of molecular-based methods has yielded new insights about its etiology, but the impact of viral etiologies on early outcomes is still unclear.METHODS: Seventy-seven infants with bronchiolitis who were under two years of age and visited an emergency unit were included. Using molecular-based methods, samples were tested for 12 different respiratory viruses. Logistic regression models were used to identify clinical and virological variables associated with the main endpoints: hospital admission and ICU admission.RESULTS: We identified at least one virus in 93.5% of patients, and coinfections were found in nearly 40% of patients. RSV was the most common pathogen (63.6%), followed by rhinovirus (39%). Identification of RSV was only associated with an increased risk of hospital admission in the univariate model. Younger age and enterovirus infection were associated with an increased risk of hospital admission, while atopy of a first-degree relative showed a protective effect. Prematurity was associated with an increased risk of admission to the ICU. Coinfections were not associated with worse outcomes.CONCLUSIONS: Molecular-based methods resulted in high rates of viral identification but did not change the significant role of RSV in acute bronchiolitis. Younger age and enterovirus infection were risk factors for hospital admission, while prematurity appeared to be a significant risk factor for admission to the ICU in acute viral bronchiolitis.en
dc.description.affiliationHosp Israelita Albert Einstein, Dept Saude Materno Infantil, São Paulo, Brazil
dc.description.affiliationHosp Israelita Albert Einstein, Ctr Pesquisa Expt, Inst Ensino & Pesquisa, São Paulo, Brazil
dc.description.affiliationHosp Israelita Albert Einstein, UPA, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Virol Lab, Inst Trop Med, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Fac Med, Hosp Clin, Inst Crianca, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Fac Med, Hosp Clin, Inst Crianca, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipSociedade Beneficiente Israelita Brasileira Hospital Israelita Albert Einstein
dc.format.extent1133-1137
dc.identifierhttp://dx.doi.org/10.1590/S1807-59322010001100014
dc.identifier.citationClinics. São Paulo: Hospital Clinicas, Univ São Paulo, v. 65, n. 11, p. 1133-1137, 2010.
dc.identifier.doi10.1590/S1807-59322010001100014
dc.identifier.issn1807-5932
dc.identifier.scieloS1807-59322010001100014
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/32052
dc.identifier.wosWOS:000288492000014
dc.language.isoeng
dc.publisherHospital Clinicas, Univ São Paulo
dc.relation.ispartofClinics
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBronchiolitisen
dc.subjectRespiratory Syncytial Virusen
dc.subjectInfanten
dc.subjectHospitalizationen
dc.subjectCoinfectionsen
dc.titleHigh Rate of Viral Identification and Coinfections in Infants with Acute Bronchiolitisen
dc.typeinfo:eu-repo/semantics/article
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