Bone mineral density in juvenile systemic lupus erythematosus

dc.contributor.authorCastro, Tania Caroline Monteiro de [UNIFESP]
dc.contributor.authorTerreri, Maria Teresa Ramos Ascensão [UNIFESP]
dc.contributor.authorSzejnfeld, Vera Lucia [UNIFESP]
dc.contributor.authorCastro, Charlles Heldan de Moura [UNIFESP]
dc.contributor.authorFisberg, Mauro [UNIFESP]
dc.contributor.authorGabay, M. [UNIFESP]
dc.contributor.authorHilário, Maria Odete Esteves [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2015-06-14T13:29:48Z
dc.date.available2015-06-14T13:29:48Z
dc.date.issued2002-10-01
dc.description.abstractWe evaluated spine bone mineral density (BMD) in Brazilian children with juvenile systemic lupus erythematosus (JSLE) in order to detect potential predictors of reduction in bone mass. A cross-sectional study of BMD at the lumbar spine level (L2-L4) was conducted on 16 female JSLE patients aged 6-17 years. Thirty-two age-matched healthy girls were used as control. BMD at the lumbar spine was measured by dual-energy X-ray absorptiometry. Weight, height and pubertal Tanner stage were determined in patients and controls. Disease duration, mean daily steroid doses, mean cumulative steroid doses and JSLE activity measured by the systemic lupus erythematosus disease activity index (SLEDAI) were determined for all JSLE patients based on their medical charts. All parameters were used as potential determinant factors for bone loss. Lumbar BMD tended to be lower in the JSLE patients, however, this difference was not statistically significant (P = 0.10). No significant correlation was observed in JSLE girls between BMD and age, height, Tanner stage, disease duration, corticosteroid use or disease activity. We found a weak correlation between BMD and weight (r = 0.672). In the JSLE group we found no significant parameters to correlate with reduced bone mass. Disease activity and mean cumulative steroid doses were not related to BMD values. We did not observe reduced bone mass in female JSLE.en
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de Pediatria
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de Medicina
dc.description.affiliationUnifespUNIFESP, EPM, Depto. de Pediatria
dc.description.affiliationUnifespUNIFESP, EPM, Depto. de Medicina
dc.description.sourceSciELO
dc.format.extent1159-1163
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X2002001000008
dc.identifier.citationBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 35, n. 10, p. 1159-1163, 2002.
dc.identifier.doi10.1590/S0100-879X2002001000008
dc.identifier.fileS0100-879X2002001000008.pdf
dc.identifier.issn0100-879X
dc.identifier.scieloS0100-879X2002001000008
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/1529
dc.identifier.wosWOS:000179717000008
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsAcesso aberto
dc.subjectSystemic lupus erythematosusen
dc.subjectChildrenen
dc.subjectAdolescentsen
dc.subjectBone mineral densityen
dc.subjectOsteoporosisen
dc.subjectCorticosteroidsen
dc.titleBone mineral density in juvenile systemic lupus erythematosusen
dc.typeArtigo
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