Period of Hyperbaric Oxygen Delivery Leads to Different Degrees of Hepatic Ischemia/Reperfusion Injury in Rats

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dc.citation.issue2
dc.citation.volume48
dc.contributor.authorChaves, J. C.
dc.contributor.authorNeto, F. S.
dc.contributor.authorIkejiri, A. T.
dc.contributor.authorBertoletto, P. R.
dc.contributor.authorTeruya, R.
dc.contributor.authorSantos Simoes, R. [UNIFESP]
dc.contributor.authorTikazawa, E. H.
dc.contributor.authorLiu, J. B.
dc.contributor.authorCarrara, F. L.
dc.contributor.authorTaha, M. O. [UNIFESP]
dc.contributor.authorFagundes, D. J. [UNIFESP]
dc.coverageNew York
dc.date.accessioned2020-08-21T17:00:01Z
dc.date.available2020-08-21T17:00:01Z
dc.date.issued2016
dc.description.abstractBackground. This study evaluated the morphology of the rat liver when hyperbaric oxygen (HBO) was used at various stages of ischemia and reperfusion. Methods. Thirty-two male Wistar rats, subjected to 30 minutes of hepatic ischemia and 30 minutes of reperfusion, were randomly assigned as follows: GIR (n = 8), control without HBO; GHBO/I (n = 8), in which HBO was applied only during ischemia; GHBO/R (n = 8), HBO only during reperfusion; and GHBO/IR (n = 8), HBO during both ischemia and reperfusion. Feasibility scores of hepatocytes were determined by assessing 8 items related to liver injury. Results. The histologic injury score of the hepatic specimens was significantly lower in the GHBO/I group (79.0 +/- 0.1) compared with the GIR group (135.0 +/- 0.1). HBO was not effective when applied during reperfusion (GHBO/R, 151.3 +/- 0.1) or during the ischemia plus reperfusion period (GHBO/IR, 131.0 +/- 0.1). The sum was significantly higher (P < .05) in HBO-treated animals during the reperfusion period (ie, in the GHBO/R group compared with any of the other groups). Conclusions. A favorable effect was obtained when HBO was administered early during ischemia. HBO given in later periods of reperfusion was associated with a more severe sum index percentage of liver damage.en
dc.description.affiliationFed Univ Grande Dourados, Sch Med, Dourados, MS, Brazil
dc.description.affiliationUniv Fed Mato Grosso do Sul, Dept Surg, Mato Grosso, MS, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Morphol & Genet, Rua Sena Madureira,1500 Vila Clementino, Sao Paulo, Brazil
dc.description.affiliationMarilia Med Sch, Marilia, SP, Brazil
dc.description.affiliationAnhembi Morumbi Univ, Sch Med, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Surg, Surg Tech & Expt Surg Div, Rua Sena Madureira,1500 Vila Clementino, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Morphol & Genet, Rua Sena Madureira,1500 Vila Clementino, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Surg, Surg Tech & Expt Surg Div, Rua Sena Madureira,1500 Vila Clementino, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent516-520
dc.identifierhttp://dx.doi.org/10.1016/j.transproceed.2015.11.035
dc.identifier.citationTransplantation Proceedings. New York, v. 48, n. 2, p. 516-520, 2016.
dc.identifier.doi10.1016/j.transproceed.2015.11.035
dc.identifier.issn0041-1345
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57841
dc.identifier.wosWOS:000375240300053
dc.language.isoeng
dc.publisherElsevier Science Inc
dc.relation.ispartofTransplantation Proceedings
dc.relation.ispartof14th International Small Bowel Transplant Symposium (ISBTS)
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.titlePeriod of Hyperbaric Oxygen Delivery Leads to Different Degrees of Hepatic Ischemia/Reperfusion Injury in Ratsen
dc.typeinfo:eu-repo/semantics/article
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