Langmuir films containing ibuprofen and phospholipids

dc.contributor.authorGeraldo, Vananelia P. N.
dc.contributor.authorPavinatto, Felippe J.
dc.contributor.authorNobre, Thatyane M.
dc.contributor.authorCaseli, Luciano [UNIFESP]
dc.contributor.authorOliveira, Osvaldo N.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:31:16Z
dc.date.available2016-01-24T14:31:16Z
dc.date.issued2013-02-20
dc.description.abstractThis study shows the incorporation of ibuprofen, an anti-inflammatory drug, in Langmuir monolayers as cell membrane models. Significant effects were observed for dipalmitoyl phosphatidyl choline (DPPC) monolayers with relevant changes in the elasticity of the monolayer. Dipalmitoyl phosphatidyl glycerol (DPPG) monolayers were affected by small concentrations of ibuprofen, from 1 to 5 mol%. for both types of monolayer, ibuprofen could penetrate into the hydrophobic part of the monolayer, which was confirmed with polarization-modulated infrared reflection-absorption spectroscopy (PM-IRRAS). Brewster angle microscopy (BAM) images showed that ibuprofen prevents the formation of large domains of DPPC. the pharmacological action should occur primarily with penetration of ibuprofen via electrically neutral phospholipid headgroups of the membrane. (c) 2013 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv São Paulo, Inst Fis Sao Carlos, BR-13560970 Sao Carlos, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Inst Ciencias Ambientais Quim & Farmaceut, Diadema, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Inst Ciencias Ambientais Quim & Farmaceut, Diadema, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshiprede nBioNet (Brazil)
dc.format.extent99-106
dc.identifierhttp://dx.doi.org/10.1016/j.cplett.2012.12.064
dc.identifier.citationChemical Physics Letters. Amsterdam: Elsevier B.V., v. 559, p. 99-106, 2013.
dc.identifier.doi10.1016/j.cplett.2012.12.064
dc.identifier.fileWOS000314728300018.pdf
dc.identifier.issn0009-2614
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35978
dc.identifier.wosWOS:000314728300018
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofChemical Physics Letters
dc.rightsAcesso aberto
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.titleLangmuir films containing ibuprofen and phospholipidsen
dc.typeArtigo
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