Cochrane report - A systematic review of mannitol therapy for acute ischemic stroke and cerebral parenchymal hemorrhage

dc.contributor.authorBereczki, Daniel
dc.contributor.authorLiu, Ming
dc.contributor.authorPrado, Gilmar Fernandes do [UNIFESP]
dc.contributor.authorFekete, Istvan
dc.contributor.institutionUniv Debrecen
dc.contributor.institutionW China Univ Med Sci
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.abstractBackground-Mannitol was reported to decrease cerebral edema associated with tissue damage and is used to treat acute stroke in many countries.Summary of Review-We tested whether there is any evidence from unconfounded randomized clinical trials that treatment with mannitol reduces short- and long-term case fatality and dependency if administered after ischemic stroke or cerebral parenchymal hemorrhage. Trials were identified by the standard search strategy of the Cochrane Collaboration Stroke Review Group. A supplementary MEDLINE search was performed, and the Chinese Stroke Trials Register and the Latin-American databank LILACS were checked. A search was performed of master's and PhD degree theses in the databank of Sao Paulo University and in abstracts of medical congresses on neurology and neurosurgery during 1965-1997 in Brazil. Investigators were contacted for unpublished information. Only truly randomized unconfounded clinical trials were eligible for inclusion. Two of the reviewers independently extracted data from the trials. Data synthesis and analysis was performed with the use of the Cochrane Review Manager software RevMan version 4.0.4).Conclusions-Only 1 trial fulfilled the inclusion criteria. The number of included patients was small, and the follow-up was short. Case fatality, the proportion of dependent patients, and side effects were not reported and were not available from the investigators. As a result of lack of appropriate randomized trials, currently no conclusion can be drawn on the effects of mannitol in acute stroke. The routine use of mannitol in all patients with acute stroke is not supported by evidence from randomized controlled clinical trials.en
dc.description.affiliationUniv Debrecen, Dept Neurol, H-4012 Debrecen, Hungary
dc.description.affiliationW China Univ Med Sci, Dept Neurol, Univ Hosp 1, Chengdu 610041, Sichuan, Peoples R China
dc.description.affiliationUniv Fed Sao Paulo, Dept Internal Med, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Internal Med, Sao Paulo, Brazil
dc.description.provenanceMade available in DSpace on 2018-06-18T12:12:07Z (GMT). No. of bitstreams: 0 Previous issue date: 2000-11-01en
dc.description.sourceWeb of Science
dc.identifier.citationStroke. Philadelphia: Lippincott Williams & Wilkins, v. 31, n. 11, p. 2719-2722, 2000.
dc.publisherLippincott Williams & Wilkins
dc.rightsAcesso aberto
dc.subjectrandomized controlled trialsen
dc.subjectstroke, acuteen
dc.subjecttreatment outcomeen
dc.titleCochrane report - A systematic review of mannitol therapy for acute ischemic stroke and cerebral parenchymal hemorrhageen