Metabolic profile response to administration of epigallocatechin-3-gallate in high-fat-fed mice

dc.contributor.authorMoreno, Mayara Franzoi [UNIFESP]
dc.contributor.authorDe Laquila, Rachel [UNIFESP]
dc.contributor.authorOkuda, Marcos Hiromu [UNIFESP]
dc.contributor.authorLira, Fabio Santos de [UNIFESP]
dc.contributor.authorSouza, Gabriel Inacio de Morais Honorato de [UNIFESP]
dc.contributor.authorSouza, Claudio Teodoro de
dc.contributor.authorTelles, Monica Marques [UNIFESP]
dc.contributor.authorRibeiro, Eliane Beraldi [UNIFESP]
dc.contributor.authorNascimento, Claudia Maria da Penha Oller do [UNIFESP]
dc.contributor.authorOyama, Lila Missae [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionFac Integradas Coracao Jesus FAINC
dc.contributor.institutionUniv Estadual Paulista
dc.contributor.institutionUniv Southern Santa Catarina
dc.description.abstractBackground: Obesity is associated with increased adipose tissue and glucose intolerance. High-fat diets (HFDs) are known to induce obesity and increase proinflammatory adipokines. the consumption of green tea may improve the health of obese individuals because it contains a potent antioxidant that has effects on body weight, energy expenditure and serum cholesterol concentrations.Methods: We examined the effects of epigallocatechin-3-gallate (EGCG) (50 mg/kg body weight per day) or saline after 30 or 60 days of treatment. Mice were distributed into four groups: 1) NS: normolipidic diet receiving saline; 2) NE: normolipidic diet receiving EGCG; 3) HFS: high-fat diet receiving saline; 4) HFE: high-fat diet receiving EGCG.Results: We observed that administration of a HFD plus EGCG treatment for 60 days reduced delta weight, the relative weights of the mesenteric adipose tissue (MES), retroperitonial adipose tissue (RET), epididymal adipose tissue (EPI), the sum of the adipose tissues (SAT), reduced triacylglycerol (TG) and improved both high-density lipoprotein (HDL) cholesterol levels and the adiponectin/STA ratio when compared with HFS.Conclusions: Our results suggest that the chronic administration of EGCG (60 days) promoted a significant improvement in glucose tolerance, decreased adipose tissue deposits, weight mass, TG and HDL-C only when associated with high-fat diet treatment.en
dc.description.affiliationUniversidade Federal de São Paulo, EPM, Dept Fisiol, São Paulo, Brazil
dc.description.affiliationFac Integradas Coracao Jesus FAINC, Santo Andre, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, UNESP, Dept Phys Educ, Immunometab Res Grp, Presidente Prudente, SP, Brazil
dc.description.affiliationUniv Southern Santa Catarina, Hlth Sci Unit, Lab Exercise Biochem & Physiol, Criciuma, SC, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Ciencias Biol, Diadema, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, EPM, Dept Fisiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Ciencias Biol, Diadema, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 2009/14373-8
dc.identifier.citationDiabetology & Metabolic Syndrome. London: Biomed Central Ltd, v. 6, 7 p., 2014.
dc.publisherBiomed Central Ltd
dc.relation.ispartofDiabetology & Metabolic Syndrome
dc.rightsAcesso aberto
dc.subjectHigh-fat dieten
dc.subjectAdipose tissueen
dc.titleMetabolic profile response to administration of epigallocatechin-3-gallate in high-fat-fed miceen
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