Relation of asymmetrical dimethylarginine levels with renal outcomes in hypertensive patients with and without type 2 diabetes mellitus

dc.citation.issue3
dc.citation.volumev. 32
dc.contributor.authorTriches, Cristina B. [UNIFESP]
dc.contributor.authorQuinto, Marie [UNIFESP]
dc.contributor.authorMayer, Saurus [UNIFESP]
dc.contributor.authorBatista, Marcelo [UNIFESP]
dc.contributor.authorZanella, Maria Teresa [UNIFESP]
dc.coverageNew York
dc.date.accessioned2020-07-20T16:31:21Z
dc.date.available2020-07-20T16:31:21Z
dc.date.issued2018
dc.description.abstractAim: The aim of the study was to evaluate the association between high plasma ADMA levels, a biomarker of endothelial dysfunction, with the progression of albuminuria and chronic kidney disease (CKD) in hypertensive patients, with and without type 2 diabetes mellitus. Methods: We successfully contacted 213 of 644 patients who had been evaluated between 2004 and 2005 and for whom basal data were available. After the exclusion of 51 patients, 162 hypertensive patients who were free from albuminuria were stratified into the following 4 groups according to the presence of diabetes and plasma ADMA percentiles: general hypertensive patients with high levels of plasma ADMA (> P4 or ADMA > 0.61 mu mol/L), general hypertensive patients with low levels of plasma ADMA (<= P4), diabetic hypertensive patients with high levels of plasma ADMA (> P4), and diabetic hypertensive patients with low levels of plasma ADMA (<= P4). Results: The patients were prospectively evaluated over 5.8 years. High ADMA levels were associated with the progression of albuminuria in hypertensive patients, with and without type 2 diabetes. Major increases in the ADMA value during follow-up were associated with the progression of CKD, and direct correlations between ADMA changes and GFR changes were observed in the whole group and in the subgroup of diabetic patients. Conclusions: We suggest that high plasma ADMA levels might be a biomarker of renal disease progression and might even be an early predictor of albuminuria and its progression to the late stages of renal disease in hypertensive and diabetic hypertensive patients. (C) 2017 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniv Fed Sao Paulo, Endocrinol Div, Rua Diogo de Faria 307, BR-04037000 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Nephrol Div, Rua Botucatu 740, BR-04023900 Sao Paulo, SP, Brazil
dc.description.affiliationHosp Israelita Albert Einstein, Res & Educ Inst, Ave Albert Einstein 627-701, BR-05652900 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Endocrinol Div, Rua Diogo de Faria 307, BR-04037000 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Nephrol Div, Rua Botucatu 740, BR-04023900 Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo/FAPESP
dc.description.sponsorshipIDFAPESP: 04/8486-0
dc.format.extent316-320
dc.identifierhttp://dx.doi.org/10.1016/j.jdiacomp.2017.12.006
dc.identifier.citationJournal Of Diabetes And Its Complications. New York, v. 32, n. 3, p. 316-320, 2018.
dc.identifier.doi10.1016/j.jdiacomp.2017.12.006
dc.identifier.issn1056-8727
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55904
dc.identifier.wosWOS:000427810500011
dc.language.isoeng
dc.publisherElsevier Science Inc
dc.relation.ispartofJournal Of Diabetes And Its Complications
dc.rightsAcesso restrito
dc.subjectAsymmetrical dimethylarginineen
dc.subjectCardiovascular risk factorsen
dc.subjectType 2 diabetes mellitusen
dc.subjectMetabolic syndromeen
dc.subjectAlbuminuriaen
dc.subjectChronic kidney diseaseen
dc.titleRelation of asymmetrical dimethylarginine levels with renal outcomes in hypertensive patients with and without type 2 diabetes mellitusen
dc.typeArtigo
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