Estudo do efeito de estimulação elétrica em ratos com osteoporose induzida pela lesão medular
Data
2010
Autores
Amorim, Beatriz Oliveira 
Orientadores
Medalha, Carla Christina
Tipo
Trabalho de conclusão de curso
Título da Revista
ISSN da Revista
Título de Volume
Resumo
A osteoporose é uma das complicações que acorrem após a lesão medular. A
desnervação decorrente dessa lesão altera a atividade das células do tecido ósseo,
aumentando o número de osteoclastos que são responsáveis pela reabsorção da matriz
óssea e a estimulação elétrica visa diminuir essa perda por meio do efeito piezelétrico. Esse
estudo analisou a eficácia desse recurso na prevenção da osteoporose induzida pela lesão
medular. Dois grupos de animais foram submetidos a lesão medular cirúrgica e tratados por
meio da estimulação elétrica de baixa intensidade (freqüência de 1.5 MHz, ciclo de trabalho
1:4, intensidade 30 mW/cm2) em 12 sessões de vinte minutos, três vezes por semana, a
partir do 1° dia pós-cirúrgico. Após o tratamento os animais foram sacrificados por perfusão
transcardíaca, os ossos foram retirados e analisados por densitometria, teste de flexão e
análise histológica
Osteoporosis is a usual complication after spinal cord injury. The denervation deriving from that injury alters the activity of cells in the bone tissue, increasing the number of osteoclasts, which are responsible for the absorption of bone matrix and electrical stimulation aims to reduce that loss through the piezoelectric effect. The aim of the present study was to examine the effectiveness of the electrical stimulation on prevention of osteoporosis induced by spinal cord injury. Two groups of animals were undergone to a surgery inducing the spinal cord injury, and were treated through electrical stimulation of low intensity (frequency of 1.5 MHz, 1:4 cycle of work, 30 mW/cm2 intensity) in 12 sessions of twenty minutes, three times a week, from day 1 post-surgery. After treatment the animals were sacrificed by deep anesthesia and bones from posterior limb were removed. The bones were analyzed by densitometry, testing of bending and by histological analysis.
Osteoporosis is a usual complication after spinal cord injury. The denervation deriving from that injury alters the activity of cells in the bone tissue, increasing the number of osteoclasts, which are responsible for the absorption of bone matrix and electrical stimulation aims to reduce that loss through the piezoelectric effect. The aim of the present study was to examine the effectiveness of the electrical stimulation on prevention of osteoporosis induced by spinal cord injury. Two groups of animals were undergone to a surgery inducing the spinal cord injury, and were treated through electrical stimulation of low intensity (frequency of 1.5 MHz, 1:4 cycle of work, 30 mW/cm2 intensity) in 12 sessions of twenty minutes, three times a week, from day 1 post-surgery. After treatment the animals were sacrificed by deep anesthesia and bones from posterior limb were removed. The bones were analyzed by densitometry, testing of bending and by histological analysis.
Descrição
Citação
AMORIM, Beatriz Oliveira. Estudo do efeito de estimulação elétrica em ratos com osteoporose induzida pela lesão medular. 2010. 25 f. Trabalho de conclusão de curso de graduação (Fisioterapia) - Instituto de Saúde e Sociedade (ISS), Universidade Federal de São Paulo (UNIFESP), Santos, 2010.