Alteration in Ikaros expression promotes B-1 cell differentiation into phagocytes

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dc.citation.issue2
dc.citation.volume223
dc.contributor.authorde Oliveira, Vivian Cristina [UNIFESP]
dc.contributor.authorPires Sodre, Ana Clara [UNIFESP]
dc.contributor.authorGomes, Caio Perez [UNIFESP]
dc.contributor.authorMoretti, Nilmar Silvio [UNIFESP]
dc.contributor.authorPesquero, Joao Bosco
dc.contributor.authorPopi, Ana Flavia [UNIFESP]
dc.coverageJena
dc.date.accessioned2020-07-08T13:09:50Z
dc.date.available2020-07-08T13:09:50Z
dc.date.issued2018
dc.description.abstractIkaros is a broad transcription factor pointed as a critical regulator of lymphocyte development. Recent reports have emphasized that distinct isoforms of Ikaros control the dichotomy of the hematopoietic system into lymphoid and myeloid lineages. In addition, expression of dominant-negative isoforms of Ikaros is linked to abnormal hematopoiesis, which could culminate in hematological disorders due to loss of function of the protein. B-1 cells are an intriguing subtype of B-lymphocytes that preserves some myeloid characteristics. These cells are able to differentiate into phagocytes (B-1CDP B-1 cell derived phagocytes) in vitro and in vivo. During such process, reprogramming of gene expression occurs: lymphoid genes are turned off, while expression of myeloid genes is increased. This study aims to investigate whether Ikaros could be related to the control of B-1 cell plasticity. Interestingly, Ikaros expression by B-1CDP cells Was found to be relatively low, and the protein is abnormally localized in the cytoplasm. Moreover, the isoforms expressed by B-1 cells are different from those expressed by other lymphocytes, with expression of active isoforms being almost absent in B-1CDP. Based on these findings, Ikaros could be an important factor driving the differentiation and proliferation of B-1 cells.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Microbiol Imunol & Parasitol, Disciplina Imunol, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Biol Mol, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Microbiol Imunol & Parasitol, Disciplina Parasitol, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Microbiol Imunol & Parasitol, Disciplina Imunol, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Biol Mol, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Microbiol Imunol & Parasitol, Disciplina Parasitol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFAPESP
dc.description.sponsorshipIDFAPESP: 2015/01986-2
dc.format.extent252-257
dc.identifierhttp://dx.doi.org/10.1016/j.imbio.2017.10.006
dc.identifier.citationImmunobiology. Jena, v. 223, n. 2, p. 252-257, 2018.
dc.identifier.doi10.1016/j.imbio.2017.10.006
dc.identifier.issn0171-2985
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54240
dc.identifier.wosWOS:000419263000013
dc.language.isoeng
dc.publisherElsevier Gmbh, Urban & Fischer Verlag
dc.relation.ispartofImmunobiology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectIkarosen
dc.subjectB-1 cellsen
dc.subjectB-1CDP cellsen
dc.subjectMyeloid differentiationen
dc.titleAlteration in Ikaros expression promotes B-1 cell differentiation into phagocytesen
dc.typeinfo:eu-repo/semantics/article
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