Impairment in Anthropometric Parameters and Body Composition in Females with Classical 21-Hydroxylase Deficiency

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dc.contributor.authorGoncalves, Ezequiel Moreira
dc.contributor.authorValente de Lemos-Marini, Sofia Helena
dc.contributor.authorMello, Maricilda Palandi de
dc.contributor.authorMatias Baptista, Maria Tereza
dc.contributor.authorRodrigues D'Souza-Li, Lilia Freire
dc.contributor.authorBaldin, Alexandre Duarte
dc.contributor.authorGomes Carvalho, Wellington Roberto
dc.contributor.authorFarias, Edson Santos
dc.contributor.authorGuerra-Junior, Gil
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2018-06-15T18:07:32Z
dc.date.available2018-06-15T18:07:32Z
dc.date.issued2009-06-01
dc.description.abstractThe aim of this study was to evaluate the physical measurements and body composition of female patients with the classic form of congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency. Twenty-eight girls with CAH were classified according to both hormonal control (well or not well controlled) and the clinical form of the disease (simple virilizing or salt-wasting). In the control group, 112 healthy individuals were included, divided into two subgroups (male and female). Both patients and controls were subdivided by age into three groups according to pubertal stage: <= 10 years (prepubertal), 11-15 years (pubertal), and >= 15 years (postpubertal). Anthropometrical evaluations and bioelectrical impedance were used to obtain the physical measurement and body composition data. The patients with the simple virilizing form presented higher values for BMI, waist, arm fat area, and fat mass percentage. The not well controlled group presented shorter leg length. Values obtained for BMI as well as for arm fat area, brachial circumference, waist, hip, bi-iliac diameter and fat mass percentage were significantly higher in the patients than in the controls, whereas leg length, hand size and the percentages of water and lean mass were lower. Alterations in body composition were observed in all age groups, mainly by increase of fat mass with age. After puberty, impairments in limb measurements (leg, hand and foot) were more evident. Patients with CAH presented differences in anthropometric parameters but mainly in body composition. Hence, more comprehensive and careful anthropometric evaluation during monitoring of patients with CAH is recommended.en
dc.description.affiliationUniv Estadual Campinas, Fac Med Sci, Dept Pediat, BR-13083970 Campinas, SP, Brazil
dc.description.affiliationUniv Estadual Campinas, Mol Biol & Genet Engn Ctr, BR-13083970 Campinas, SP, Brazil
dc.description.affiliationUniv Estadual Campinas, Dept Internal Med, Fac Med Sci, BR-13083970 Campinas, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent519-529
dc.identifierhttp://dx.doi.org/10.1515/JPEM.2009.22.6.519
dc.identifier.citationJournal Of Pediatric Endocrinology & Metabolism. Berlin: Walter De Gruyter Gmbh, v. 22, n. 6, p. 519-529, 2009.
dc.identifier.doi10.1515/JPEM.2009.22.6.519
dc.identifier.issn0334-018X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/44535
dc.identifier.wosWOS:000267771700008
dc.language.isoeng
dc.publisherWalter De Gruyter Gmbh
dc.relation.ispartofJournal Of Pediatric Endocrinology & Metabolism
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectanthropometryen
dc.subjectbody compositionen
dc.subjectcongenital adrenal hyperplasiaen
dc.subjectbioelectric impedanceen
dc.titleImpairment in Anthropometric Parameters and Body Composition in Females with Classical 21-Hydroxylase Deficiencyen
dc.typeinfo:eu-repo/semantics/article
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