Nebulized ceftazidime in experimental pneumonia caused by partially resistant Pseudomonas aeruginosa

Página do item simplificado
dc.contributor.authorFerrari, Fabio
dc.contributor.authorLu, Qin
dc.contributor.authorGirardi, Cassio [UNIFESP]
dc.contributor.authorPetitjean, Olivier
dc.contributor.authorMarquette, Charles-Hugo
dc.contributor.authorWallet, Frederic
dc.contributor.authorRouby, Jean-Jacques
dc.contributor.authorExpt ICU Study Grp
dc.contributor.institutionUniv Paris 06
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionAvicenne Hosp
dc.contributor.institutionUniv Med
dc.date.accessioned2016-01-24T13:58:47Z
dc.date.available2016-01-24T13:58:47Z
dc.date.issued2009-10-01
dc.description.abstractVentilator-associated pneumonia caused by Pseudomonas aeruginosa with impaired sensitivity to ceftazidime is frequent in critically ill patients. the aim of the study was to compare lung tissue deposition and antibacterial efficiency between nebulized and intravenous administrations of ceftazidime in ventilated piglets with pneumonia caused by Pseudomonas aeruginosa with impaired sensitivity to ceftazidime.Ceftazidime was administered 24 h following the intra-bronchial inoculation of Pseudomonas aeruginosa (minimum inhibitory concentration = 16 mu g ml(-1)), either by nebulization (25 mg kg(-1) every 3 h, n = 6) or by continuous intravenous infusion (90 mg kg(-1) over 24 h after an initial rapid infusion of 30 mg kg(-1), n = 6). Four non-treated inoculated animals served as controls. All piglets were killed 48 h (intravenous and control groups) or 51 h (aerosol group) after inoculation. Lung tissue concentrations and lung bacterial burden were assessed on multiple post-mortem sub-pleural lung specimens [(lower limit of quantitation = 10(2) colony forming unit (cfu g(-1))].Ceftazidime trough lung tissue concentrations following nebulization were greater than steady-state lung tissue concentrations following continuous intravenous infusion [median and interquartile range, 24.8 (12.6-59.6) mu g g(-1) vs. 6.1 (4.6-10.8) mu g g(-1)] (p < 0.001). After 24 h of ceftazidime administration, 83% of pulmonary segments had bacterial counts < 10(2) cfu g(-1) following nebulization and only 30% following intravenous administration (p < 0.001). in control animals, 10% of lung segments had bacterial counts < 10(2) cfu g(-1) 48 h following bronchial inoculation.Nebulized ceftazidime provides more efficient bacterial killing in ventilated piglets with pneumonia caused by Pseudomonas aeruginosa with impaired sensitivity to ceftazidime.en
dc.description.affiliationUniv Paris 06, Hop La Pitie Salpetriere, AP HP, Reanimat Polyvalente Pierre Viars,Dept Anesthesie, F-75013 Paris, France
dc.description.affiliationUniv Paris 06, Hop La Pitie Salpetriere, Polyvalent Intens Care Unit Pierre Viars, F-75013 Paris, France
dc.description.affiliationUniversidade Federal de São Paulo, Dept Anesthesiol, Escola Paulista Med, São Paulo, Brazil
dc.description.affiliationAvicenne Hosp, Dept Pharmacol, Bobigny, France
dc.description.affiliationUniv Med, DHURE, Lille, France
dc.description.affiliationUniv Med, INSERM, U416, Lille, France
dc.description.affiliationUniv Med, Dept Bacteriol, Lille, France
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Anesthesiol, Escola Paulista Med, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent1792-1800
dc.identifierhttp://dx.doi.org/10.1007/s00134-009-1605-2
dc.identifier.citationIntensive Care Medicine. New York: Springer, v. 35, n. 10, p. 1792-1800, 2009.
dc.identifier.doi10.1007/s00134-009-1605-2
dc.identifier.issn0342-4642
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/31849
dc.identifier.wosWOS:000270171900022
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofIntensive Care Medicine
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectNebulizationen
dc.subjectCeftazidimeen
dc.subjectPneumoniaen
dc.subjectPseudomonas aeruginosaen
dc.subjectMechanical ventilationen
dc.subjectTreatmenten
dc.titleNebulized ceftazidime in experimental pneumonia caused by partially resistant Pseudomonas aeruginosaen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
EPM - Artigos