Sudden unexpected death in an adolescent with epilepsy: All roads lead to the heart?

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dc.contributor.authorPinto, Kylvia G. F. D.
dc.contributor.authorScorza, Fulvio Alexandre [UNIFESP]
dc.contributor.authorArida, Ricardo Mario [UNIFESP]
dc.contributor.authorCavalheiro, Esper Abrão [UNIFESP]
dc.contributor.authorMartins, Luciana D.
dc.contributor.authorMachado, Helio R.
dc.contributor.authorSakamoto, Américo Ceiki [UNIFESP]
dc.contributor.authorTerra, Vera C.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-15T16:39:15Z
dc.date.available2018-06-15T16:39:15Z
dc.date.issued2011-03-01
dc.description.abstractThe incidence of sudden unexpected death in epilepsy (SUDEP) has been estimated from 0.5-1.4/1,000 person-years in people with treated epilepsy, and 9/1,000 person-years in candidates for epilepsy surgery. Potential risk factors for SUDEP include: age, early onset of epilepsy, duration of epilepsy, uncontrolled seizures, seizure type and winter temperatures. The arrythmogenic side-effect of antiepileptic drugs and seizures may increase the risk of SUDEP. In this report, we describe a patient with prolonged post-ictal tachycardia in EEG video recordings with a typical case of SUDEP: a 16-year-old boy with medically intractable complex partial seizures. Magnetic resonance imaging revealed left mesial temporal sclerosis. During non-invasive video-EEG monitoring, the patient presented a post-ictal heart rate increased for five hours. Two months after video-EEG, he died from SUDEP during a tonic-clonic secondary generalized seizure. The possibility of cardiac involvement in the pathogenesis of SUDEP has been suggested by many studies. Evaluation of this patient with EEG-video monitoring, including measurement of heart rate, contributed to an identification of ictal tachycardia that may have played a role in the SUDEP. Premature mortality seems to be increased in patients with epilepsy, and cardiac abnormalities may be a possible cause of SUDEP. (Cardiol J 2011; 18, 2: 194-196)en
dc.description.affiliationUniv Sao Paulo, Ctr Cirurgia Epilepsia, Dept Neurociencias & Ciencias Comportamento, Fac Med Ribeirao Preto,Ctr Cirurgia Epilepsia CIR, BR-14048900 Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Disciplina Neurol Expt, Escola Paulista Med UNIFESP EPM, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Fisiol, Escola Paulista Med UNIFESP EPM, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Disciplina Neurol Expt, Escola Paulista Med UNIFESP EPM, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Fisiol, Escola Paulista Med UNIFESP EPM, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipINCT/MCT
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent194-196
dc.identifierhttps://journals.viamedica.pl/cardiology_journal/article/view/21274/16878
dc.identifier.citationCardiology Journal. Gdansk: Via Medica, v. 18, n. 2, p. 194-196, 2011.
dc.identifier.fileWOS000293941000014.pdf
dc.identifier.issn1897-5593
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/43252
dc.identifier.wosWOS:000293941000014
dc.language.isoeng
dc.publisherVia Medica
dc.relation.ispartofCardiology Journal
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectsudden deathen
dc.subjectepilepsyen
dc.subjectEEGen
dc.subjecthearten
dc.titleSudden unexpected death in an adolescent with epilepsy: All roads lead to the heart?en
dc.typeinfo:eu-repo/semantics/article
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