Atypical antipsychotic drugs and tardive dyskinesia: relevance of D-2 receptor affinity

Data
2004-03-01
Tipo
Artigo
Título da Revista
ISSN da Revista
Título de Volume
Resumo
Evidence suggests atypical antipsychotic treatment is associated with a Lower incidence of tardive dyskinesia (TD) than typical antipsychotic drugs, and is a potential antidyskinetic treatment. We present the case of a middle-aged woman never previously exposed to antipsychotic treatment who developed TD after 6 months of olanzapine monotherapy. Substitution of quetiapine for otanzapine alleviated her TD symptoms. the case demonstrates that atypical antipsychotic drugs have different effects in relation to TD. Potential psychopharmacological mechanisms explaining these differences are discussed, highlighting the importance of D-2 receptor occupancy by atypical antipsychotic drugs for TD.
Descrição
Citação
Journal of Psychopharmacology. London: Sage Publications Ltd, v. 18, n. 1, p. 124-127, 2004.
Coleções