Treatment with dexamethasone alters yawning behavior induced by cholinergic but not dopaminergic agonist
Data
1999-01-15
Autores
Hipólide, Débora Cristina 
Lobo, Leticia Leite
Neumann, Beatrice Rosaura Guaragna
Tufik, Sergio
Tipo
Artigo
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ISSN da Revista
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Resumo
Because stressful manipulations have been reported to modify drug-induced yawning, the present study investigated the effects of single and repeated treatment with a synthetic glucocorticoid, dexamethasone (DEXA) on apomorphine- and pilocarpine-induced yawning in male rats. Neither single nor repeated treatment with DEXA altered apomorphine-induced yawning. Single administration of DEXA, however, resulted in an increased number of yawns induced by pilocarpine. Conversely, repeated administration of DEXA led to a decreased number of yawns induced by pilocarpine. In conclusion, the present findings show that dopaminergic and cholinergic are distinctly altered by DEXA, in terms of yawning behavior when animals received DEXA. (C) 1999 Elsevier Science, Inc.
Descrição
Citação
Physiology & Behavior. Oxford: Pergamon-elsevier Science Ltd, v. 65, n. 4-5, p. 829-832, 1999.