Prions: the danger of biochemical weapons
Xavier, Eric Almeida [UNIFESP]
Is part ofFood Science and Technology (Campinas)
MetadataShow full item record
The knowledge of biotechnology increases the risk of using biochemical weapons for mass destruction. Prions are unprecedented infectious pathogens that cause a group of fatal neurodegenerative diseases by a novel mechanism. They are transmissible particles that are devoid of nucleic acid. Due to their singular characteristics, Prions emerge as potential danger since they can be used in the development of such weapons. Prions cause fatal infectious diseases, and to date there is no therapeutic or prophylactic approach against these diseases. Furthermore, Prions are resistant to food-preparation treatments such as high heat and can find their way from the digestive system into the nervous system; recombinant Prions are infectious either bound to soil particles or in aerosols. Therefore, lethal Prions can be developed by malicious researchers who could use it to attack political enemies since such weapons cause diseases that could be above suspicion.
CitationFood Science and Technology (Campinas). Sociedade Brasileira de Ciência e Tecnologia de Alimentos, v. 34, n. 3, p. 433-440, 2014.
Prions danger to the environment
Prions risk alert
- Em verificação - Geral 
Showing items related by title, author, creator and subject.
DNA converts cellular prion protein into the beta-sheet conformation and inhibits prion peptide aggregation Cordeiro, Y.; Machado, F.; Juliano, Luiz [UNIFESP]; Juliano, Maria Aparecida [UNIFESP]; Brentani, R. R.; Foguel, D.; Silva, J. L. (Amer Soc Biochemistry Molecular Biology Inc, 2001-12-28)The main hypothesis for prion diseases proposes that the cellular protein (PrPc) can be altered into a misfolded, beta-sheet-rich isoform (PrPSc), which in most cases undergoes aggregation. in an organism infected with ...
Prnp/prion protein regulates the secretion of exosomes modulating cav1/caveolin-1-suppressed autophagy Dias, Marcos V. S.; Teixeira, Bianca L.; Rodrigues, Bruna R.; Sinigaglia-Coimbra, Rita [UNIFESP]; Porto-Carreiro, Isabel; Roffe, Martin; Hajj, Glaucia N. M.; Martins, Vilma R. (Univ Federal Juiz Fora, Campus Univ, 2016)Prion protein modulates many cellular functions including the secretion of trophic factors by astrocytes. Some of these factors are found in exosomes, which are formed within multivesicular bodies (MVBs) and secreted into ...