Oxandrolone use in adult burn patients. Systematic review and meta-analysis

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Date
2014-01-01Author
Real, Daniel Sundfeld Spiga [UNIFESP]
Reis, Rodrigo Pacheco
Piccolo, Monica Sarto
Okamoto, Regina H.
Gragnani, Alfredo [UNIFESP]
Ferreira, Lydia Masako [UNIFESP]
Type
ArtigoISSN
0102-8650Is part of
Acta Cirurgica BrasileiraDOI
10.1590/S0102-86502014001700013Metadata
Show full item recordAbstract
PURPOSE:This study is a systematic literature review and meta-analysis concerning the use of a testosterone synthetic analog, oxandrolone, and its use in severe adult burns.METHODS:Randomized prospective clinical studies, in English, Portuguese or Spanish, were sought on the following databases: MEDLINE, COCHRANE, EMBASE and LILACS. There was no restriction in relation to the publication date.RESULTS: This search produced 24 studies on MEDLINE and twelve articles were presented on the COCHRANE database .Sixteen were excluded due to the title not being related to this search or by including children. Of the eigth residual studies, after adaptation to the inclusion criteria, only four were selected. After analyzing the results, two were discarded since they did not present adequate patient characterization and the facts on these articles were analyzed differently from the others, hindering the meta-analysis.CONCLUSION:The analysis of the available data demonstrated significant benefits (p<0.05) considering lesser loss of corporal mass, lesser nitrogen loss, and shorter donor area healing time, when Oxandrolone was used, comparatively with the control group (placebo or not).
Citation
Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 29, p. 68-76, 2014.Keywords
OxandroloneBurns
Adults
Systematic review
Meta-analysis
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