Depression during gestation in adolescent mothers interferes with neonatal neurobehavior

Depression during gestation in adolescent mothers interferes with neonatal neurobehavior

Author Barros, Marina Carvalho de Moraes Autor UNIFESP Google Scholar
Mitsuhiro, Sandro Sendin Autor UNIFESP Google Scholar
Chalem, Elisa Google Scholar
Laranjeira, Ronaldo Autor UNIFESP Google Scholar
Guinsburg, Ruth Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Objective: To compare the neurobehavior of neonates born to adolescent mothers with and without depression during gestation. Methods: This prospective cross-sectional study included healthy term neonates born to adolescent mothers with untreated depression during gestation, without exposure to legal or illicit drugs, and compared them with infants born to adolescent mothers without psychiatric disorders. Maternal psychiatric diagnoses were assessed by the Composite International Diagnostic Interview (CIDI 2.1) and neonatal neurobehavior by the Neonatal Intensive Care Unit Network Neurobehavioral Scale (NNNS) at 24 to 72 hours of life. Neurobehavioral outcomes were analyzed by ANOVA adjusted for confounders. Results: 37 infants born to mothers with depression during gestation were compared to 332 infants born to mothers without psychiatric disorders. Infants of mothers with depression had smaller head circumferences. Significant interactions of maternal depression and male gender, gestational age > 40 weeks, regional anesthesia during delivery, vaginal delivery, and infant head circumference ≥ 34 cm were found. Worse performance was noted in the following neonatal neurobehavioral parameters: arousal, excitability, lethargy, hypotonicity, and signs of stress and abstinence. Conclusion: Infants born to adolescent mothers with depression exhibit some behavioral changes in the first days of life. These changes are associated with infant sex, gestational age, type of anesthesia, mode of delivery, and head circumference.
Keywords Depressive disorder
pregnancy in adolescence
infant behavior
Language English
Date 2013-12-01
Published in Revista Brasileira de Psiquiatria. Associação Brasileira de Psiquiatria - ABP, v. 35, n. 4, p. 353-359, 2013.
ISSN 1516-4446 (Sherpa/Romeo)
Publisher Associação Brasileira de Psiquiatria - ABP
Extent 353-359
Access rights Open access Open Access
Type Article
SciELO ID S1516-44462013000400353 (statistics in SciELO)

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