Developed pressure data may provide misinformation when used alone to evaluate systolic function in isovolumetric left ventricle preparations

Developed pressure data may provide misinformation when used alone to evaluate systolic function in isovolumetric left ventricle preparations

Author Murad, Neif Autor UNIFESP Google Scholar
Tucci, Paulo José Ferreira Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract We report data showing that developed pressure (DPmax) may lead to opposite conclusion with respect to maximal developed circumferential wall stress (smax) when used to assess contractile function in left ventricle isovolumic preparations. Isovolumetric left ventricle preparations of rats with cardiac hypertrophy (H; N = 10) induced by isoproterenol administration showed higher DPmax (174 ± 14 mmHg) than control (C; N = 8) animals (155 ± 12 mmHg) or rats with regression (R; N = 8) of hypertrophy (144 ± 11 mmHg). In contrast, the estimated smax for C (145 ± 26 kdynes/cm2) and R (133 ± 17 kdynes/cm2) was higher than for H (110 ± 13 kdynes/cm2). According to Laplace's law, the opposite results of DPmax and smax may depend on the increased mass/volume left ventricle ratio of the hypertrophied hearts, which favored pressure generation. These results clearly show that DPmax should be used with caution to analyze systolic function.
Keywords contractile function
developed pressure
wall stress
cardiac hypertrophy
Laplace's law
Language English
Date 1999-06-01
Published in Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 32, n. 6, p. 773-776, 1999.
ISSN 0100-879X (Sherpa/Romeo, impact factor)
Publisher Associação Brasileira de Divulgação Científica
Extent 773-776
Origin http://dx.doi.org/10.1590/S0100-879X1999000600014
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000080896000014
SciELO ID S0100-879X1999000600014 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/790

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