Now showing items 1-20 of 225

    • Prenatal and lactation nicotine exposure affects Sertoli cell and gonadotropin levels in rats 

      Paccola, C. C. [UNIFESP]; Miraglia, S. M. [UNIFESP] (Bioscientifica Ltd, 2016)
      Nicotine is largely consumed in the world as a component of cigarettes. It can cross the placenta and reach the milk of smoking mothers. This drug induces apoptosis, affects sex hormone secretion, and leads to male ...
    • Novel frameshift variant in gene SALL4 causing Okihiro syndrome 

      Alves, Leandro Ucela; Alvarez Perez, Ana Beatriz [UNIFESP]; Alonso, Luis Garcia [UNIFESP]; Otto, Paulo Alberto; Mingroni-Netto, Regina Celia (Elsevier Science Bv, 2016)
      Okihiro syndrome, Duane-radial ray syndrome or acro-reno-ocular syndrome (OMIM #607323) are alternative denominations describing an extremely variable condition, characterized by several radial defects of the upper limbs ...
    • Prenatal and lactation nicotine exposure affects Sertoli cell and gonadotropin levels in rats 

      Paccola, C. C. [UNIFESP]; Miraglia, S. M. [UNIFESP] (Bioscientifica Ltd, 2016)
      Nicotine is largely consumed in the world as a component of cigarettes. It can cross the placenta and reach the milk of smoking mothers. This drug induces apoptosis, affects sex hormone secretion, and leads to male ...
    • Novel frameshift variant in gene SALL4 causing Okihiro syndrome 

      Alves, Leandro Ucela; Alvarez Perez, Ana Beatriz [UNIFESP]; Alonso, Luis Garcia [UNIFESP]; Otto, Paulo Alberto; Mingroni-Netto, Regina Celia (Elsevier Science Bv, 2016)
      Okihiro syndrome, Duane-radial ray syndrome or acro-reno-ocular syndrome (OMIM #607323) are alternative denominations describing an extremely variable condition, characterized by several radial defects of the upper limbs ...
    • The antineoplastic busulphan impairs peritubular and Leydig cells, and vitamin B-12 stimulates spermatogonia proliferation and prevents busulphan-induced germ cell death 

      Sasso-Cerri, Estela; Oliveira, Barbara; de Santi, Fabiane [UNIFESP]; Beltrame, Flavia L. [UNIFESP]; Caneguim, Breno H. [UNIFESP]; Cerri, Paulo S. (Elsevier France-Editions Scientifiques Medicales Elsevier, 2017)
      Busulphan (Bu), an alkylating agent used for bone marrow and spermatogonial stem cell transplantation (SSCT), impairs Sertoli (SC) cells, which are necessary for the spermatogonial stem cell (SSC) homing during transplantation. ...
    • Determining the frequency of morphological characteristics in a sample of Brazilian children 

      Perrone, Eduardo [UNIFESP]; Zanolla, Thais Arbocese [UNIFESP]; Fock, Rodrigo Ambrosio [UNIFESP]; Alvarez Perez, Ana Beatriz [UNIFESP]; Brunoni, Decio (Soc Brasil Pediatria, 2017)
      Objective: To establish the frequency of 82 morphological features in a sample of Brazilian children (between 3 and 13 years old), to understand the influence of age, gender, and ethnicity. Methods: This was a cross-sectional ...
    • Patients with a Kabuki syndrome phenotype demonstrate DNA methylation abnormalities 

      Sobreira, Nara; Brucato, Martha; Zhang, Li; Ladd-Acosta, Christine; Ongaco, Chrissie; Romm, Jane; Doheny, Kimberly F.; Mingroni-Netto, Regina C.; Bertola, Debora; Kim, Chong A.; Perez, Ana B. A. [UNIFESP]; Melaragno, Maria I. [UNIFESP]; Valle, David; Meloni, Vera A.; Bjornsson, Hans T. (Nature Publishing Group, 2017)
      Kabuki syndrome is a monogenic disorder caused by loss of function variants in either of two genes encoding histone-modifying enzymes. We performed targeted sequencing in a cohort of 27 probands with a clinical diagnosis ...
    • Summaries of plenary, symposia, and oral sessions at the XXII World Congress of Psychiatric Genetics, Copenhagen, Denmark, 12-16 October 2014 

      Aas, Monica; Blokland, Gabriella A. M.; Chawner, Samuel J. R. A.; Choi, Shing-Wan; Estrada, Jose; Forsingdal, Annika; Friedrich, Maximilian; Ganesham, Suhas; Hall, Lynsey; Haslinger, Denise; Huckins, Laura; Loken, Erik; Malan-Muller, Stefanie; Martin, Joanna; Misiewicz, Zuzanna; Pagliaroli, Luca; Pardinas, Antonio F.; Pisanu, Claudia; Quadri, Giorgia; Santoro, Marcos L. [UNIFESP]; Shaw, Alex D.; Ranlund, Siri; Song, Jie; Tesli, Martin; Tropeano, Maria; van der Voet, Monique; Wolfe, Kate; Cormack, Freida K.; DeLisi, Lynn (Lippincott Williams & Wilkins, 2016)
      The XXII World Congress of Psychiatric Genetics, sponsored by the International Society of Psychiatric Genetics, took place in Copenhagen, Denmark, on 12-16 October 2014. A total of 883 participants gathered to discuss the ...
    • Intubação orotraqueal e disfunção temporomandibular: estudo longitudinal controlado 

      Battistella, Claudia Branco [UNIFESP]; Machado, Flavia Ribeiro [UNIFESP]; Juliano, Yara; Guimaraes, Antonio Sergio [UNIFESP]; Tanaka, Cassia Emi [UNIFESP]; de Souza Garbim, Cristina Tala [UNIFESP]; da Rocha Fonseca, Paula de Maria [UNIFESP]; Sanches, Monique Lalue [UNIFESP] (Elsevier Science Inc, 2016)
      Background and objectives: To determine the incidence of signs and symptoms of temporomandibular disorder in elective surgery patients who underwent orotracheal intubation. Methods: This was a longitudinal controlled study ...
    • Osteocytic connexin 43 is not required for the increase in bone mass induced by intermittent PTH administration in male mice 

      Pacheco-Costa, R. [UNIFESP]; Davis, H. M.; Atkinson, E. G.; Katchburian, E. [UNIFESP]; Plotkin, L. I.; Reginato, R. D. [UNIFESP] (Jmni, 2016)
      Objective: To investigate whether osteocytic connexin 43 (Cx43) is required for the bone response to intermittent PTH administration, and whether the connexin is involved in maintaining the bone matrix. Methods: Human ...
    • Late reproductive analysis in rat male offspring exposed to nicotine during pregnancy and lactation 

      Miranda-Spooner, M. [UNIFESP]; Paccola, C. C. [UNIFESP]; Neves, F. M. O. [UNIFESP]; de Oliva, S. U. [UNIFESP]; Miraglia, S. M. [UNIFESP] (Wiley-Blackwell, 2016)
      We previously observed that nicotine, administered to rats (Wistar) during pregnancy and lactation periods, provokes, in the progeny, late morphofunctional alterations in Leydig cell, body weight increase in adulthood ...
    • Resveratrol improves reproductive parameters of adult rats varicocelized in peripuberty 

      Mendes, Talita Biude [UNIFESP]; Paccola, Camila Cicconi [UNIFESP]; de Oliveira Neves, Flavia Macedo [UNIFESP]; Simas, Joana Nogueres [UNIFESP]; Vaz, Andre da Costa [UNIFESP]; Cabral, Regina Elisabeth L. [UNIFESP]; Vendramini, Vanessa [UNIFESP]; Miraglia, Sandra Maria [UNIFESP] (Bioscientifica Ltd, 2016)
      The aim of this study was to investigate the protective action of resveratrol against the reproductive damage caused by left-sided experimental varicocele. There was a reduction of testicular major axis in the varicocele ...
    • AGK-BRAF gene fusion is a recurrent event in sporadic pediatric thyroid carcinoma 

      Cordioli, Maria Isabel C. V. [UNIFESP]; Moraes, Lais [UNIFESP]; Carvalheira, Gianna [UNIFESP]; Sisdelli, Luiza [UNIFESP]; Alves, Maria Teresa S. [UNIFESP]; Delcelo, Rosana [UNIFESP]; Monte, Osmar; Longui, Carlos A.; Cury, Adriano N.; Cerutti, Janete M. [UNIFESP] (Wiley-Blackwell, 2016)
      Thyroid cancer is the fastest increasing cancer worldwide in all age groups. Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer in both adults and children. PTC genomic landscape has been extensively ...
    • Predictors of Cognitive and Functional Decline in Patients With Alzheimer Disease Dementia From Brazil 

      Oliveira, Fabricio F. [UNIFESP]; Chen, Elizabeth S. [UNIFESP]; Smith, Marilia C. [UNIFESP]; Bertolucci, Paulo H. F. [UNIFESP] (Lippincott Williams & Wilkins, 2016)
      Little is known on how risk factors for Alzheimer disease (AD) dementia affect disease progression, much less for populations with low mean schooling, whereas the transcription of APOE may be regulated by nongenetic factors. ...
    • Biflorin induces cytotoxicity by DNA interaction in genetically different human melanoma cell lines 

      Lima Ralph, Ana Carolina; Calcagno, Danielle Queiroz; da Silva Souza, Luciana Gregorio; Gomes de Lemos, Telma Leda; Montenegro, Raquel Carvalho; Cardoso Smith, Marilia de Arruda [UNIFESP]; de Vasconcellos, Marne Carvalho (Pergamon-Elsevier Science Ltd, 2016)
      Cancer is a public health problem and the second leading cause of death worldwide. The incidence of cutaneous melanoma has been notably increasing, resulting in high aggressiveness and poor survival rates. Taking into ...
    • Epigenetic regulation of metalloproteinases and their inhibitors in rotator cuff tears 

      Leal, Mariana Ferreira [UNIFESP]; Santos, Leonardo Caires dos [UNIFESP]; Oliveira, Adrielle Martins de [UNIFESP]; Belangero, Paulo Santoro [UNIFESP]; Figueiredo, Eduardo Antonio [UNIFESP]; Cohen, Carina [UNIFESP]; Alves, Felipe de Seixas [UNIFESP]; Yanaguizawa, Wania Hiromi [UNIFESP]; Andreoli, Carlos Vicente [UNIFESP]; Pochini, Alberto de Castro [UNIFESP]; Ejnisman, Benno [UNIFESP]; Smith, Marilia Cardoso [UNIFESP]; Alves, Maria Teresa de Seixas [UNIFESP]; Cohen, Moises [UNIFESP] (Public Library Science, 2017)
      Rotator cuff tear is a common orthopedic condition. Metalloproteinases (MMP) and their inhibitors (TIMP) seem to play a role in the development of joint injuries and in the failure of tissue healing. However, the mechanisms ...
    • ABI3, a component of the WAVE2 complex, is potentially regulated by PI3K/AKT pathway 

      Moraes, Lais [UNIFESP]; Zanchin, Nilson I. T.; Cerutti, Janete M. [UNIFESP] (Impact Journals Llc, 2017)
      We previously reported that ABI3 expression is lost in follicular thyroid carcinomas and its restoration significantly inhibited cell growth, invasiveness, migration, and reduced tumor growth in vivo. The mechanistic basis ...
    • AC(2-26) peptide and serine protease of Bothrops atrox similarly induces angiogenesis without triggering local and systemic inflammation in a murine model of dorsal skinfold chamber 

      Molas, Rafaela Batista; de Paula-Silva, Marina; Masood, Rehana; Ullah, Anwar; Gimenes, Alexandre Dantas [UNIFESP]; Oliani, Sonia Maria [UNIFESP] (Pergamon-Elsevier Science Ltd, 2017)
    • Cytogenomic assessment of the diagnosis of 93 patients with developmental delay and multiple congenital abnormalities: The Brazilian experience 

      Zanardo, Evelin Aline; Dutra, Roberta Lelis; Piazzon, Flavia Balbo; Dias, Alexandre Torchio; Novo-Filho, Gil Monteiro; Nascimento, Amom Mendes; Montenegro, Marilia Moreira; Damasceno, Jullian Gabriel; Rosa Madia, Fabricia Andreia; Moura Machado da Costa, Thais Virginia; Melaragno, Maria Isabel [UNIFESP]; Kim, Chong Ae; Kulikowski, Leslie Domenici (Hospital Clinicas, Univ Sao Paulo, 2017)
      OBJECTIVE: The human genome contains several types of variations, such as copy number variations, that can generate specific clinical abnormalities. Different techniques are used to detect these changes, and obtaining an ...
    • Single-nucleotide polymorphisms in genes related to the hypothalamic-pituitary-adrenal axis as risk factors for posttraumatic stress disorder 

      Carvalho, Carolina M [UNIFESP].; Coimbra, Bruno M. [UNIFESP]; Ota, Vanessa K. [UNIFESP]; Mello, Marcelo F. [UNIFESP]; Belangero, Sintia I. [UNIFESP] (Wiley, 2017)
      Posttraumatic stress disorder (PTSD) is a common psychiatric disorder. The etiology of PTSD is multifactorial, depending on many environmental and genetic risk factors, and the exposure to life or physical integrity-threatening ...