Now showing items 1-10 of 10
Schizophrenia and fragile sites
(Lippincott Williams & Wilkins, 1997-12-01)
Frequency of Werner helicase 1367 polymorphism and age-related morbidity in an elderly Brazilian population
(Associação Brasileira de Divulgação Científica, 2005-07-01)
Werner syndrome (WS) is a premature aging disease caused by a mutation in the WRN gene. The gene was identified in 1996 and its product acts as a DNA helicase and exonuclease. Some specific WRN polymorphic variants were ...
Helicobacter pylori detection in gastric biopsies, saliva and dental plaque of Brazilian dyspeptic patients
(Instituto Oswaldo Cruz, Ministério da Saúde, 2010-05-01)
Helicobacter pylori is an important human pathogen that causes chronic gastritis and is associated with the development of peptic ulcer disease and gastric malignancies. The oral cavity has been implicated as a potential ...
Werner helicase polymorphism is not associated with Alzheimer's disease
(Ios Press, 2004-12-01)
Alzheimer disease (AD) is the most common neurodegenerative disorder in the elderly and is also considered a progeroid genetic syndrome. The etiology of AD is complex and the mechanisms underlying its pathophysiology remains ...
cagA positive Helicobacter pylori in Brazilian children related to chronic gastritis
(Brazilian Society of Infectious Diseases, 2006-08-01)
Helicobacter pylori is a spiral-shaped Gram-negative bacterium. It colonizes the gastric mucosa of humans and persists for decades if not treated. Helicobacter pylori infection affects more than half of the world's population ...
Interleukin-8 gene polymorphism -251T > A and Alzheimer's disease
(Ios Press, 2007-01-01)
Promoter hypermethylation of CDH1, FHIT, MTAP and PLAGL1 in gastric adenocarcinoma in individuals from Northern Brazil
(W J G Press, 2007-05-14)
AIM: To evaluate the methylation status of CDH1, FHIT, MTAP and PLAGL1 promoters and the association of these findings with clinico-pathological characteristics.METHODS: Methylation-specific PCR (MSP) assay was performed ...
Promoter methylation analysis of SIRT3, SMARCA5, HTERT and CDH1 genes in aging and Alzheimer's disease
(Ios Press, 2008-01-01)
Longevity related genes were investigated concerning promoter methylation. SIRT3, SMARCA5, HTERT and CDH1 promoters were analyzed in peripheral blood in relation to gender, age and Alzheimer's disease ( AD). Methylation ...
Differential chromosome sensitivity to 5-azacytidine in Alzheimer's disease
Background: The methylation process in the DNA has been considered a control mechanism of gene activity, connected with genetic imprinting. 5-Azacytidine (5-AZC) is known to be a demethylation agent. Objective: We studied ...
Relationship between Helicobacter pylori detection and an increased risk of infection in childhood
The risk of developing gastric cancer is believed to be related to differences among Helicobacter pylori strains and the inflammatory responses mediated by host genetic factors. H. pylori infection is acquired at an early ...