Heparan sulfates and heparins: similar compounds performing the same functions in vertebrates and invertebrates?

Heparan sulfates and heparins: similar compounds performing the same functions in vertebrates and invertebrates?

Author Nader, Helena Bonciani Autor UNIFESP Google Scholar
Chavante, Suely Ferreira Autor UNIFESP Google Scholar
Santos, Elizeu Antunes dos Google Scholar
Oliveira, Fernanda Wanderley Google Scholar
Paiva, José Fernandes de Autor UNIFESP Google Scholar
Jerônimo, Selma Maria Bezerra Google Scholar
Medeiros, Guilherme Fulgencio de Autor UNIFESP Google Scholar
Abreu, Luiz Roberto Diz de Autor UNIFESP Google Scholar
Leite, Edda Lisboa Google Scholar
Sousa-Filho, João Felipe de Google Scholar
Castro, Rodrigo de Aquino Autor UNIFESP Google Scholar
Toma, Leny Autor UNIFESP Google Scholar
Tersariol, Ivarne Luis dos Santos Autor UNIFESP Google Scholar
Porcionatto, Marimélia Aparecida Autor UNIFESP Google Scholar
Dietrich, Carl Peter Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade Federal do Rio Grande do Norte
Universidade de Mogi das Cruzes
Abstract The distribution and structure of heparan sulfate and heparin are briefly reviewed. Heparan sulfate is a ubiquitous compound of animal cells whose structure has been maintained throughout evolution, showing an enormous variability regarding the relative amounts of its disaccharide units. Heparin, on the other hand, is present only in a few tissues and species of the animal kingdom and in the form of granules inside organelles in the cytoplasm of special cells. Thus, the distribution as well as the main structural features of the molecule, including its main disaccharide unit, have been maintained through evolution. These and other studies led to the proposal that heparan sulfate may be involved in the cell-cell recognition phenomena and control of cell growth, whereas heparin may be involved in defense mechanisms against bacteria and other foreign materials. All indications obtained thus far suggest that these molecules perform the same functions in vertebrates and invertebrates.
Keywords heparin - occurrence and function
heparan sulfate - occurrence and function
heparin - invertebrates
heparan sulfate - invertebrates
heparin and heparan sulfate - structure
Language English
Date 1999-05-01
Published in Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 32, n. 5, p. 529-538, 1999.
ISSN 0100-879X (Sherpa/Romeo, impact factor)
Publisher Associação Brasileira de Divulgação Científica
Extent 529-538
Origin http://dx.doi.org/10.1590/S0100-879X1999000500005
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000080489600005
SciELO ID S0100-879X1999000500005 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/775

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