Abdominal wall healing in incisional hernia using different biomaterials in rabbits

Abdominal wall healing in incisional hernia using different biomaterials in rabbits

Author Aramayo, Ana Letícia Gomes Autor UNIFESP Google Scholar
Lopes Filho, Gaspar de Jesus Autor UNIFESP Google Scholar
Barbosa, Cirênio de Almeida Google Scholar
Amaral, Vânia da Fonseca Google Scholar
Costa, Luciano Assis Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
University of Medical Sciences of Minas Gerais FCMMG Surgery Department
Federal University of Minas Gerais Department of General Pathology
Abstract PURPOSE: To investigate abdominal wound healing using specific biomaterials in incisional hernias. METHODS: Incisional hernias were produced in 40 rabbits, after that they were reoperated with or without the use of meshes: PREMILENE® (PPL), ULTRAPRO® (UP), PROCEED® (PCD) or repairing without mesh (TRANSPALB). After 30 days a macroscopic and microscopic study of the part withdrawn from the abdominal wall was performed. RESULTS: Macroscopic: adhesion Area: PPL> UP and PCD (p = 0.031). Vascularization: PPL> UP and PCD (p = 0.001). PPL groups (p = 0.032) and PCD (p <0.001) showed greater meshes shrinkages when compared to UP. Microscopic: neutrophils: PCD> PPL, UP and TRANSPALB (p = 0.010); eosinophils: PPL> UP, and TRANSPALB PCD (p = 0.010); granulation tissue: PPL and PCD> UP and TRANSPALB (p <0.001); macrophages : PPL, UP and PCD> TRANSPALB (p <0.001); lymphocytes: PPL and PCD> UP (p = 0.009) and TRANSPALB (p <0.001); giant cells: PPL, UP and PCD> TRANSPALB (p <0.001); viscera adhered: PPL and UP> PCD and TRANSPALB (p <0.001). CONCLUSION: All types of meshes caused the formation of adhesions. The UP and PCD groups showed lower area and vascularization of the adhesions. The PPL and PCD groups showed higher meshes shrinkage and there was a predominance of acute inflammatory process in the PCD group.
Keywords Wound Healing
Abdominal Wall. Hernia, Ventral
Surgical Mesh
Materials Testing
Animal Experimentation
Language English
Date 2013-04-01
Published in Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 28, n. 4, p. 307-316, 2013.
ISSN 0102-8650 (Sherpa/Romeo, impact factor)
Publisher Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
Extent 307-316
Origin http://dx.doi.org/10.1590/S0102-86502013000400011
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000317522300011
SciELO ID S0102-86502013000400011 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/7681

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