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dc.contributor.authorHeinke, Thais [UNIFESP]
dc.contributor.authorEspiríto Santo, Kleber Simões do
dc.contributor.authorLongatto Filho, Adhemar
dc.contributor.authorStávale, João Norberto [UNIFESP]
dc.date.accessioned2015-06-14T13:45:11Z
dc.date.available2015-06-14T13:45:11Z
dc.date.issued2013-01-01
dc.identifierhttp://dx.doi.org/10.1590/S0102-86502013000100008
dc.identifier.citationActa Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 28, n. 1, p. 48-54, 2013.
dc.identifier.issn0102-8650
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/7540
dc.description.abstractPURPOSE: To evaluate the relationship between microvascular density and the expression of vascular endothelial growth factor (VEGF) and KIT as possible markers of angiogenic stimulus in astrocytic tumors and correlate it with histopathological grading. METHODS: We enrolled 99 surgical specimens of supratentorial astrocytic tumors for analysis of VEGF and KIT and subsequent correlation with MVD and grading. RESULTS: KIT and VEGF expression correlated with microvascular density (p<0.005) and both VEGF and microvascular density correlated with grading (p<0.005). KIT had no significant relationship with grading (p=0.657). CONCLUSION: KIT and VEGF constitute important pathways in the angiogenesis of astrocytomas and therefore are promising prognostic tools and options for therapeutic intervention.en
dc.format.extent48-54
dc.language.isoeng
dc.publisherSociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.relation.ispartofActa Cirurgica Brasileira
dc.rightsAcesso aberto
dc.subjectGliomaen
dc.subjectNeovascularization, Pathologicen
dc.subjectImmunohistochemistryen
dc.titleVascular endothelial growth factor and KIT expression in relation with microvascular density and tumor grade in supratentorial astrocytic tumorsen
dc.typeArtigo
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionClinical Hospital Luzia de Pinho Melo
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.description.affiliationUNIFESP-EPM Investigative Pathology Division
dc.description.affiliationClinical Hospital Luzia de Pinho Melo
dc.description.affiliationUniversity of São Paulo Faculty of Medicine Laboratory of Medical Investigation
dc.description.affiliationUnifespUNIFESP, EPM, Investigative Pathology Division
dc.identifier.fileS0102-86502013000100008.pdf
dc.identifier.scieloS0102-86502013000100008
dc.identifier.doi10.1590/S0102-86502013000100008
dc.description.sourceSciELO
dc.identifier.wosWOS:000313866600007


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