Now showing items 21-40 of 248

    • P2X(7) receptor and klotho expressions in diabetic nephropathy progression 

      Rodrigues, A. M. [UNIFESP]; Serralha, R. S. [UNIFESP]; Farias, C. [UNIFESP]; Punaro, Giovana Rita [UNIFESP]; Fernandes, M. J. S. [UNIFESP]; Higa, Elisa Mieko Suemitsu [UNIFESP] (Springer, 2018)
      Diabetes mellitus is characterized by increased levels of reactive oxygen species (ROS), leading to high levels of adenosine triphosphate (ATP) and the activation of purinergic receptors (P2X(7)), which results in cell ...
    • The role of digital health in supporting the achievement of the Sustainable Development Goals (SDGs) 

      Novillo-Ortiz, David; Marin, Heimar de Fatima [UNIFESP]; Saigi-Rubio, Francesc (Elsevier Ireland Ltd, 2018)
    • Study protocol of a multicenter randomized controlled trial of mindfulness training to reduce burnout and promote quality of life in police officers: the POLICE study 

      Trombka, Marcelo; Demarzo, Marcelo Marcos Piva [UNIFESP]; Bacas, Daniel Campos; Antonio, Sonia Beira [UNIFESP]; Cicuto, Karen [UNIFESP]; Salvo, Vera Lucia Morais Antonio de [UNIFESP]; Claudino, Felipe Cesar Almeida; Ribeiro, Leticia; Christopher, Michael; Garcia-Campayo, Javier; Rocha, Neusa Sica (Biomed Central Ltd, 2018)
      Background: Police officers experience a high degree of chronic stress. Policing ranks among the highest professions in terms of disease and accident rates. Mental health is particularly impacted, evidenced by elevated ...
    • Vitamin D Receptor Taql Polymorphism Is Associated With Reduced Follicle Number in Women Utilizing Assisted Reproductive Technologies 

      Reginatto, Mila W.; Pizarro, Bartira M.; Antunes, Roberto A.; Mancebo, Ana C. A.; Hoffmann, Luisa; Fernandes, Pamela; Areas, Patricia; Chiamolera, Maria Izabel [UNIFESP]; Silva, Rosane; Souza, Maria do Carmo Borges de; Bloise, Enrrico; Ortiga-Carvalho, Tania M. (Frontiers Media Sa, 2018)
      Purpose: Calcitriol, or 1,25-hydroxycholecalciferol, is the active form of vitamin D. It binds and activates vitamin D receptor (VDR). Infertility and defective folliculogenesis have been observed in female vdr-knockout mice
    • Homeostasis in a feed forward loop gene regulatory motif 

      Antoneli, Fernando [UNIFESP]; Golubitsky, Martin; Stewart, Ian (Academic Press Ltd- Elsevier Science Ltd, 2018)
      The internal state of a cell is affected by inputs from the extra-cellular environment such as external temperature. If some output, such as the concentration of a target protein, remains approximately constant as inputs ...
    • Synergistic effect of apoptosis and necroptosis inhibitors in cisplatin-induced nephrotoxicity 

      Tristao, Vivian Regina [UNIFESP]; Pessoa, Edson A. [UNIFESP]; Nakamichi, Renata [UNIFESP]; Reis, Luciana A. [UNIFESP]; Batista, Marcelo Costa [UNIFESP]; Durao Junior, Marcelino de Souza [UNIFESP]; Martins Monte, Julio Cesar [UNIFESP] (Springer, 2016)
      Necroptosis is a nonapoptotic cell death pathway. We aim to study the effect of necrostatin-1 (a specific necroptosis inhibitor) in cisplatin-induced injury. We analyzed the effect of the combined use of inhibitors of ...
    • Efficacy and safety of subcutaneous tocilizumab versus intravenous tocilizumab in combination with traditional DMARDs in patients with RA at week 97 (SUMMACTA) 

      Burmester, Gerd R.; Rubbert-Roth, Andrea; Cantagrel, Alain; Hall, Stephen; Leszczynski, Piotr; Feldman, Daniel [UNIFESP]; Rangaraj, Madura J.; Roane, Georgia; Ludivico, Charles; Bao, Min; Rowell, Lucy; Davies, Claire; Mysler, Eduardo F. (Bmj Publishing Group, 2016)
      Objectives To evaluate the long-term efficacy and safety of subcutaneous (SC) tocilizumab (TCZ) versus intravenous (IV) TCZ, including switching formulations, in patients with rheumatoid arthritis (RA) and inadequate ...
    • Postoperative persistent chronic pain: what do we know about prevention, risk factors, and treatment 

      Kraychete, Durval Campos; Sakata, Rioko Kimiko [UNIFESP]; Carvalho Lannes, Leticia de Oliveira; Bandeira, Igor Dorea; Sadatsune, Eduardo Jun [UNIFESP] (Elsevier Science Inc, 2016)
      Background and objectives: Postoperative persistent chronic pain (POCP) is a serious health problem, disabling, undermining the quality of life of affected patients. Although more studies and research have addressed the ...
    • Translation to Brazilian Portuguese, cultural adaptation and reproducibility of the questionnaire "Ankylosing Spondylitis: What do you know?" 

      Orlandi, Aline [UNIFESP]; Brumini, Christine [UNIFESP]; Jones, Anamaria [UNIFESP]; Natour, Jamil [UNIFESP] (Associacao Paulista Medicina, 2016)
      CONTEXT AND OBJECTIVE: Ankylosing spondylitis (AS) generates inflammation and pain in entheses, peripheral joints and the spine. Education regarding AS can improve patients' disability. Thus, it is important to assess ...
    • Características clínicas e frequência de polimorfismos em TLR4 em pacientes brasileiros com espondilite anquilosante 

      Machado, Natalia Pereira [UNIFESP]; Nogueira, Eliana [UNIFESP]; Oseki, Karen [UNIFESP]; Cruz Ebbing, Pamela Carolina [UNIFESP]; Taemi Origassa, Clarice Silvia [UNIFESP]; Mohovic, Tatiane [UNIFESP]; Saraiva Camara, Niels Olsen [UNIFESP]; Pinheiro, Marcelo de Medeiros [UNIFESP] (Elsevier Science Inc, 2016)
      Objectives: Innate immunity is involved in the physiopathology of ankylosing spondylitis (AS), with the participation of Gram-negative bacteria, modulation of human leukocyte antigen (HLA) B27 and the involvement of pattern ...
    • Targeting JAK/STAT Signaling to Prevent Rejection After Kidney Transplantation: A Reappraisal 

      Baan, Carla C.; Kannegieter, Nynke M.; Felipe, Claudia Rosso [UNIFESP]; Silva, Helio Tedesco, Jr. [UNIFESP] (Lippincott Williams & Wilkins, 2016)
      The profound involvement of cytokines in allograft rejection makes the molecules that control their actions, members of the Jak-Stat pathway, ideal targets for pharmacological intervention. Numerous studies have demonstrated ...
    • Early infiltration of p40IL12(+)CCR7(+)CD11b(+) cells is critical for fibrosis development 

      Braga, Tarcio Teodoro; Correa-Costa, Matheus; Azevedo, Hatylas; Silva, Reinaldo Correia; Cruz, Mario Costa; Soares Almeida, Maira Estanislau; Hiyane, Meire Ioshie; Moreira-Filho, Carlos Alberto; Santos, Marinilce Fagundes; Perez, Katia Regina; Cuccovia, Iolanda Midea; Saraiva Camara, Niels Olsen [UNIFESP] (Wiley, 2016)
      IntroductionMacrophages are heterogeneous and thus can be correlated with distinct tissue outcomes after injury. Conflicting data have indicated that the M2-related phenotype directly triggers fibrosis. Conversely, we ...
    • Interfacial Tension 

      Leonardi, Gislaine Ricci [UNIFESP]; Monteiro e Silva, Silas A. [UNIFESP]; Guimaraes, Carina M. [UNIFESP]; Perrechil, Fabiana A. [UNIFESP]; Landgraf, Richardt G. [UNIFESP]; Friberg, Stig E. (Springer Heidelberg, 2016)
      The destabilization process was investigated for a Janus emulsion of silicone and Bixa Orellana oils stabilized by polyoxyethylene sorbitan monooleate (Tw 80) and carboxymethyl cellulose. The emulsion stabilized with Tw ...
    • A pooled analysis of nivolumab for the treatment of advanced non-small-cell lung cancer and the role of PD-L1 as a predictive biomarker 

      Aguiar, Pedro N., Jr. [UNIFESP]; Santoro, Ilka Lopes [UNIFESP]; Tadokoro, Hakaru [UNIFESP]; Lopes, Gilberto de Lima; Filardi, Bruno Andraus [UNIFESP]; Oliveira, Pedro; Castelo-Branco, Pedro; Mountzios, Giannis; de Mello, Ramon Andrade (Future Medicine Ltd, 2016)
      Background: Recent studies with nivolumab (a monoclonal antibody against programmed cell death 1 [PD-1] receptor) have shown promise non-small-cell lung cancer (NSCLC) treatment. Methods: To review available clinical trials ...
    • Adrenal fatigue does not exist: a systematic review 

      Cadegiani, Flavio A. [UNIFESP]; Kater, Claudio E. [UNIFESP] (Biomed Central Ltd, 2016)
      Background: The term "adrenal fatigue" ("AF") has been used by some doctors, healthcare providers, and the general media to describe an alleged condition caused by chronic exposure to stressful situations. Despite this, ...
    • EHRA/HRS/APHRS/SOLAECE expert consensus on Atrial cardiomyopathies: Definition, characterisation, and clinical implication 

      Goette, Andreas; Kalman, Jonathan M.; Aguinaga, Luis; Akar, Joseph; Angel Cabrera, Jose; Chen, Shih Ann; Chugh, Sumeet S.; Corradi, Domenico; D'Avila, Andre; Dobrev, Dobromir; Fenelon, Guilherme [UNIFESP]; Gonzalez, Mario; Hatem, Stephane N.; Helm, Robert; Hindricks, Gerhard; Ho, Siew Yen; Hoit, Brian; Jalife, Jose; Kim, Young-Hoon; Lip, Gregory Y. H.; Ma, Chang-Sheng; Marcus, Gregory M.; Murray, Katherine; Nogami, Akihiko; Sanders, Prashanthan; Uribe, William; Van Wagoner, David R.; Nattel, Stanley (Elsevier Science Bv, 2016)
    • Brazilian guidelines for the clinical management of paracoccidioidomycosis 

      Shikanai-Yasuda, Maria Aparecida; Mendes, Rinaldo Poncio; Colombo, Arnaldo Lopes [UNIFESP]; de Queiroz-Telles, Flavio; Goncalves Kono, Adriana Satie; Paniago, Anamaria M. M.; Nathan, Andre; Francisconi do Valle, Antonio Carlos; Bagagli, Eduardo; Benard, Gil; Ferreira, Marcelo Simao; Teixeira, Marcus de Melo; Silva-Vergara, Mario Leon; Pereira, Ricardo Mendes; Cavalcante, Ricardo de Souza; Hahn, Rosane; Durlacher, Rui Rafael; Khoury, Zarifa; de Camargo, Zoilo Pires [UNIFESP]; Moretti, Maria Luiza; Martinez, Roberto (Soc Brasileira Medicina Tropical, 2017)
      Paracoccidioidomycosis is a systemic fungal disease occurring in Latin America that is associated with rural environments and agricultural activities. However, the incidence and prevalence of paracoccidiodomycosis is ...
    • Development of a prototype immunochromatographic test for rapid diagnosis of respiratory adenovirus infection 

      Paulini, Inarei [UNIFESP]; Siqueira-Silva, Joselma; Thomaz, Luciana; Rocha, Leticia; Harsi, Charlotte; Bellei, Nancy [UNIFESP]; Granato, Celso [UNIFESP] (Elsevier Brazil, 2017)
      Human adenoviruses comprise an important group of etiologie agents that are responsible for various diseases in adults and children, such as respiratory, ocular, gastroenteric, and urinary infections. In immunocompromised ...
    • Predictive validity analysis of six reference equations for the 6-minute walk test in healthy Brazilian men: a cross-sectional study 

      Negreiros, Alexandher; Padula, Rosimeire Simprini; Bretas Bernardes, Rosane Andrea; de Moraes, Monica Vasconcelos; Pires, Raquel Simoni; Chiavegato, Luciana Dias [UNIFESP] (Associacao Brasileira Pesquisa Pos-Graduacao Fisioterapia-Abrapg-Ft, 2017)
      Background: The six-minute walk test (6MWT) is an important tool for evaluating functional capacity and exercise tolerance. The reference equations for the 6MWT in healthy subjects were established on the basis of American ...
    • Gallic Acid-Loaded Gel Formulation Combats Skin Oxidative Stress: Development, Characterization and Ex Vivo Biological Assays 

      Monteiro e Silva, Silas Arandas [UNIFESP]; Fioramonti Calixto, Giovana Maria; Cajado, Juliana; Antunes de Carvalho, Patricia Caballieri [UNIFESP]; Rodero, Camila Fernanda; Chorilli, Marlus; Leonardi, Gislaine Ricci [UNIFESP] (Mdpi Ag, 2017)
      Oxidative stress, which is a result of overproduction and accumulation of free radicals, is the main cause of several skin degenerative diseases, such as aging. Polyphenols, such as gallic acid, are an important class of ...