Pituitary glycoprotein hormone a-subunit secretion by cirrhotic patients

Pituitary glycoprotein hormone a-subunit secretion by cirrhotic patients

Author Oliveira, M.c. Google Scholar
Pizarro, C.b. Google Scholar
Cassal, A. Google Scholar
Cremonese, R. Google Scholar
Vieira, J.g.h. Autor UNIFESP Google Scholar
Institution A01
Fundação Faculdade Federal de Ciências Médicas de Porto Alegre
Universidade Federal de São Paulo (UNIFESP)
Abstract Secretion of the a-subunit of pituitary glycoprotein hormones usually follows the secretion of intact gonadotropins and is increased in gonadal failure and decreased in isolated gonadotropin deficiency. The aim of the present study was to determine the levels of the a-subunit in the serum of patients with cirrhosis of the liver and to compare the results obtained for eugonadal cirrhotic patients with those obtained for cirrhotic patients with hypogonadotropic hypogonadism. Forty-seven of 63 patients with cirrhosis (74.6%) presented hypogonadism (which was central in 45 cases and primary in 2), 7 were eugonadal, and 9 women were in normal menopause. The serum a-subunit was measured by the fluorimetric method using monoclonal antibodies. Cross-reactivity with LH, TSH, FSH and hCG was 6.5, 1.2, 4.3 and 1.1%, respectively, with an intra-assay coefficient of variation (CV) of less than 5% and an interassay CV of 5%, and sensitivity limit of 4 ng/l. The serum a-subunit concentration ranged from 36 to 6253 ng/l, with a median of 273 ng/l. The median was 251 ng/l for patients with central hypogonadism and 198 ng/l for eugonadal patients. The correlation between the a-subunit and basal LH levels was significant both in the total sample (r = 0.48, P<0.01) and in the cirrhotic patients with central hypogonadism (r = 0.33, P = 0.02). Among men with central hypogonadism there was a negative correlation between a-subunit levels and total testosterone levels (r = 0.54, P<0.01) as well as free testosterone levels (r = -0.53, P<0.01). In conclusion, although the a-subunit levels are correlated with LH levels, at present they cannot be used as markers for hypogonadism in patients with cirrhosis of the liver.
Keywords a-subunit
pituitary
gonadotropins
hypogonadism
cirrhosis
Language English
Date 1999-01-01
Published in Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 32, n. 1, p. 73-77, 1999.
ISSN 0100-879X (Sherpa/Romeo, impact factor)
Publisher Associação Brasileira de Divulgação Científica
Extent 73-77
Origin http://dx.doi.org/10.1590/S0100-879X1999000100011
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000078324100011
SciELO ID S0100-879X1999000100011 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/724

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