Anti-trypanosomal activity of 1,2,3,4,6-penta-O-galloyl-β -D-glucose isolated from Plectranthus barbatus Andrews (Lamiaceae)

Anti-trypanosomal activity of 1,2,3,4,6-penta-O-galloyl-β -D-glucose isolated from Plectranthus barbatus Andrews (Lamiaceae)

Author Santos, Roberta Tancredi dos Autor UNIFESP Google Scholar
Hiramoto, Liliane Lumi Autor UNIFESP Google Scholar
Lago, Joao Henrique Ghilardi Autor UNIFESP Google Scholar
Sartorelli, Patricia Autor UNIFESP Google Scholar
Tempone, André Gustavo Autor UNIFESP Google Scholar
Pinto, Erika Gracielle Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Instituto Adolfo Lutz Departamento de Parasitologia
Universidade de São Paulo (USP)
Instituto Plantarum de Estudos da Flora
Abstract MeOH extract from the leaves of Plectranthus barbatus Andrews (Lamiaceae), showed in vitro anti-trypanosomal activity. The bioassay-guided fractionation resulted in the isolation of a gallic acid derivative, identified as 1,2,3,4,6-penta-O-galloyl-β-D-glucose (PGG), after thorough NMR and MS spectral analysis. Finally, this compound was tested against trypomastigote forms of T. cruzi and displayed an EC50 value of 67 µM, at least 6.6-fold more effective than the standard drug benznidazole. This is the first occurrence of PGG in the Plectranthus genus and the first anti-parasitic activity described for PGG in the literature.
Keywords Plectranthus barbatus
1,2,3,4,6-penta-O-galloyl-β-D-glucose
anti-trypanosomal activity
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Date 2012-01-01
Published in SANTOS, Roberta Tancredi dos et al . Anti-trypanosomal activity of 1,2,3,4,6-penta-O-galloyl-β -D-glucose isolated from Plectranthus barbatus Andrews (Lamiaceae). Quím. Nova, São Paulo , v. 35, n. 11, p. 2229-2332, 2012
ISSN 0100-4042 (Sherpa/Romeo, impact factor)
Publisher Sociedade Brasileira de Química
Extent 2229-2332
Origin http://dx.doi.org/10.1590/S0100-40422012001100025
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000312034600025
SciELO ID S0100-40422012001100025 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/6908

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