Constituents and antiproliferative activity of extracts from leaves of Croton macrobothrys

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2011-12-01
Autores
Motta, Lucimar Barbosa da
Furlan, Cláudia Maria
Santos, Deborah Yara Alves Cursino dos
Salatino, Maria Luiza Faria
Duarte-Almeida, Joaquim Mauricio [UNIFESP]
Negri, Giuseppina [UNIFESP]
Carvalho, João Ernesto de [UNIFESP]
Ruiz, Ana Lúcia Tasca Gois
Cordeiro, Inês
Salatino, Antonio
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Croton macrobothrys Baill, Euphorbiaceae, is a tree from the Atlantic Forest in Southern Brazil, used in traditional medicine and popularly known as dragon's blood and pau-sangue. Leaf n-hexane, dichloromethane and methanol extracts were analyzed by GC/MS and evaluated for their in vitro antiproliferative activity on cell lines 786-0 (kidney), HT-29 (colon), K562 (leukemia), NCI-ADR/RES (drug resistant ovary), NCI-H460 (lung), MCF-7 (mammary), PC-3 (prostate), OVCAR-3 (ovary), U251 (glioma) and UACC-62 (melanoma). The dicloromethane extract exhibited activity against all cell lines at the concentration 25 µg/mL, in particular on cell lines NCI-H460 (GI50 0.33 μg/mL) and K5662 (GI50 0.91 μg/mL). Relevant constituents in dichloromethane extract are the alkaloids corydine and salutaridine, as well as the diterpenes geranylgeraniol and crotonin-derived clerodanes.
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Revista Brasileira de Farmacognosia. Sociedade Brasileira de Farmacognosia, v. 21, n. 6, p. 972-977, 2011.
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