Técnica de secagem por spray drying e sua aplicação na produção de extratos vegetais das espécies referenciadas na relação nacional de plantas medicinais de interesse ao sus
Data
2023-01-25
Autores
Cabral, Stefania Maria Darcie [UNIFESP]
Orientadores
Andreo, Marcio Adriano [UNIFESP]
Tipo
Trabalho de conclusão de curso de graduação
Título da Revista
ISSN da Revista
Título de Volume
Resumo
Como parte da Política Nacional de Práticas Integrativas e Complementares do SUS (Sistema Único de Saúde), o Governo Federal estabeleceu a Política Nacional de Plantas Medicinais e Fitoterápicos, com o objetivo de garantir à população brasileira o acesso seguro e o uso racional de plantas medicinais e fitoterápicos. A Relação Nacional de Plantas Medicinais de Interesse ao SUS (RENISUS) foi divulgada em 2009 e é constituída de 71 espécies vegetais. Em 2012, a Relação Nacional de Medicamentos Essenciais (RENAME) foi ampliada para medicamentos fitoterápicos e 12 medicamentos foram incluídos ao elenco de Referência Nacional de Medicamentos e Insumos Complementares para a Assistência Farmacêutica na Atenção Básica. A maioria dos medicamentos fitoterápicos registrados no Brasil apresentam-se sob a forma farmacêutica sólida, utilizando extratos secos como principal matéria-prima ativa. Uma vez que, a secagem por aspersão é uma tecnologia versátil e utilizada de forma ampla, este trabalho apresenta uma revisão sistemática, da aplicação da secagem por spray drying na obtenção de extratos secos para produção de medicamentos fitoterápicos constantes na Relação Nacional de Medicamentos Essenciais (RENAME). Os trabalhos foram pesquisados nas bases de dados científicas PUBMED, Scielo e Periódicos Capes e a busca foi realizada utilizando como palavras-chave o nome científico dos fitoterápicos constantes na RENAME, associados ao operador booleano “AND” e ao termo “spray drying”. Os resultados foram filtrados a partir do ano 2000 e, ao todo, a pesquisa nos bancos de dados mencionados retornou 104 artigos, dos quais 80 deles foram considerados neste estudo. A técnica de secagem por aspersão mostrou-se um bom método para alcançar micropartículas carregadas com um extrato, sendo adequado para preparar micropartículas contendo o extrato de 4 das 6 plantas discutidas neste estudo.
As part of the National Policy on Integrative and Complementary Practices of the SUS (Unified Health System), the Federal Government established the National Policy on Medicinal Plants and Herbal Medicines, with the objective of guaranteeing safe access to and rational use of medicinal plants to the Brazilian population. and herbal medicines. The National List of Medicinal Plants of Interest to the SUS (RENISUS) was released in 2009 and is made up of 71 plant species. In 2012, the National List of Essential Medicines (RENAME) was expanded to include herbal medicines and 12 medicines were included in the list of National Reference of Medicines and Complementary Inputs for Pharmaceutical Assistance in Primary Care. Most herbal medicines registered in Brazil are presented in solid pharmaceutical form, using dry extracts as the main active raw material. Since spray drying is a versatile and widely used technology, this work presents a systematic review of the application of spray drying to obtain dry extracts for the production of herbal medicines listed in the National List of Essential Medicines (RENAME). The works were searched in the scientific databases PUBMED, Scielo and Periódicos Capes and the search was carried out using as keywords the scientific name of the herbal medicines contained in RENAME, associated with the Boolean operator “AND” and the term “spray drying”. The results were filtered from the year 2000 and, in all, the search in the mentioned databases returned 104 articles, of which 80 were considered in this study. The spray drying technique proved to be a good method to reach microparticles loaded with an extract, being suitable to prepare microparticles containing the extract of 4 of the 6 plants discussed in this study.
As part of the National Policy on Integrative and Complementary Practices of the SUS (Unified Health System), the Federal Government established the National Policy on Medicinal Plants and Herbal Medicines, with the objective of guaranteeing safe access to and rational use of medicinal plants to the Brazilian population. and herbal medicines. The National List of Medicinal Plants of Interest to the SUS (RENISUS) was released in 2009 and is made up of 71 plant species. In 2012, the National List of Essential Medicines (RENAME) was expanded to include herbal medicines and 12 medicines were included in the list of National Reference of Medicines and Complementary Inputs for Pharmaceutical Assistance in Primary Care. Most herbal medicines registered in Brazil are presented in solid pharmaceutical form, using dry extracts as the main active raw material. Since spray drying is a versatile and widely used technology, this work presents a systematic review of the application of spray drying to obtain dry extracts for the production of herbal medicines listed in the National List of Essential Medicines (RENAME). The works were searched in the scientific databases PUBMED, Scielo and Periódicos Capes and the search was carried out using as keywords the scientific name of the herbal medicines contained in RENAME, associated with the Boolean operator “AND” and the term “spray drying”. The results were filtered from the year 2000 and, in all, the search in the mentioned databases returned 104 articles, of which 80 were considered in this study. The spray drying technique proved to be a good method to reach microparticles loaded with an extract, being suitable to prepare microparticles containing the extract of 4 of the 6 plants discussed in this study.