Cotrimoxazole enhances the in vitro susceptibility of Coccidioides posadasii to antifungals

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Date
2011-12-01Author
Cordeiro, Rossana de Aguiar
Astete-Medrano, Delia Jessica
Marques, Francisca Jakelyne de Farias
Andrade, Heuziwanne Tavares Leite
Perdigão Neto, Lauro Vieira
Tavares, Juliane Lira
Lima, Rita Amanda Chaves de
Patoilo, Kharla Kharolyni Nobre Rabelo
Monteiro, Andre Jalles
Brilhante, Raimunda Sâmia Nogueira
Rocha, Marcos Fábio Gadelha
Camargo, Zoilo Pires de [UNIFESP]
Sidrim, José Júlio Costa
Type
ArtigoISSN
0074-0276Is part of
Memórias do Instituto Oswaldo CruzDOI
10.1590/S0074-02762011000800024Metadata
Show full item recordAbstract
The aim of the present study was to evaluate the effect of cotrimoxazole on the in vitro susceptibility of Coccidioides posadasii strains to antifungals. A total of 18 strains of C. posadasii isolated in Brazil were evaluated in this study. The assays were performed in accordance with the Clinical and Laboratory Standards Institute guidelines and the combinations were tested using the checkerboard method. The minimum inhibitory concentrations were reduced by 11, 2.4, 4.3 and 3.5 times for amphotericin B, itraconazole, fluconazole and voriconazole, respectively. Moreover, it was seen that cotrimoxazole itself inhibited C. posadasii strains in vitro. The impairment of folic acid synthesis may be a potential antifungal target for C. posadasii.
Citation
Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 106, n. 8, p. 1045-1048, 2011.Collections
- EPM - Artigos [17701]