Cotrimoxazole enhances the in vitro susceptibility of Coccidioides posadasii to antifungals

Nenhuma Miniatura disponível
Data
2011-12-01
Autores
Cordeiro, Rossana de Aguiar
Astete-Medrano, Delia Jessica
Marques, Francisca Jakelyne de Farias
Andrade, Heuziwanne Tavares Leite
Perdigão Neto, Lauro Vieira
Tavares, Juliane Lira
Lima, Rita Amanda Chaves de
Patoilo, Kharla Kharolyni Nobre Rabelo
Monteiro, Andre Jalles
Brilhante, Raimunda Sâmia Nogueira
Orientadores
Tipo
Artigo
Título da Revista
ISSN da Revista
Título de Volume
Resumo
The aim of the present study was to evaluate the effect of cotrimoxazole on the in vitro susceptibility of Coccidioides posadasii strains to antifungals. A total of 18 strains of C. posadasii isolated in Brazil were evaluated in this study. The assays were performed in accordance with the Clinical and Laboratory Standards Institute guidelines and the combinations were tested using the checkerboard method. The minimum inhibitory concentrations were reduced by 11, 2.4, 4.3 and 3.5 times for amphotericin B, itraconazole, fluconazole and voriconazole, respectively. Moreover, it was seen that cotrimoxazole itself inhibited C. posadasii strains in vitro. The impairment of folic acid synthesis may be a potential antifungal target for C. posadasii.
Descrição
Citação
Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 106, n. 8, p. 1045-1048, 2011.
Coleções