Age-related testosterone decline in a Brazilian cohort of healthy military men

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dc.contributor.author Nardozza Júnior, Archimedes [UNIFESP]
dc.contributor.author Szelbracikowski, Sérgio dos Santos [UNIFESP]
dc.contributor.author Nardi, Aguinaldo Cesar [UNIFESP]
dc.contributor.author Almeida, José Carlos de [UNIFESP]
dc.date.accessioned 2015-06-14T13:43:17Z
dc.date.available 2015-06-14T13:43:17Z
dc.date.issued 2011-10-01
dc.identifier http://dx.doi.org/10.1590/S1677-55382011000500004
dc.identifier.citation International braz j urol. Sociedade Brasileira de Urologia, v. 37, n. 5, p. 591-597, 2011.
dc.identifier.issn 1677-5538
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/6647
dc.description.abstract INTRODUCTION: Androgen decline in the aging man has become a topic of increasing clinical relevance worldwide, as the reduction in testosterone levels has been reported to be accompanied by loss of muscle mass, accumulation of central adiposity, impaired mobility and increase risk of bone fractures. Although well-established in studies conducted in developed countries, progressive decline in serum testosterone levels with age has been poorly investigated in Brazil. AIM: To determine the pattern of blood testosterone concentrations decline with age in a cohort of Brazilian healthy military men. MATERIALS AND METHODS: We retrospectively reviewed data on serum testosterone measurements of healthy individuals that had undergone a routine check-up at the Military Biology Institute. Blood samples were obtained early in the morning, and total testosterone concentration was determined using a commercial chemoluminescent immunoassay. Mean values were analyzed in five age groups: < 40, 41 to 50, 51 to 60, 61 to 70, and > 70 years. MAIN OUTCOME MEASURE: Mean total testosterone levels. RESULTS: 1,623 subjects were included in the analysis; mean age was 57 years (24 to 87), and mean testosterone level was 575.5 ng/dL (25.0 to 1308.0 ng/dL). The evaluation of age-related changes in total testosterone levels revealed a progressive reduction in serum levels of this hormone with increasing age. Testosterone levels below 300 ng/dL were reported in 321 participants, a prevalence of nearly 20% in the study population. CONCLUSION: In agreement with other findings, a reduction of total testosterone levels with age was reported for healthy Brazilian men. en
dc.format.extent 591-597
dc.language.iso eng
dc.publisher Sociedade Brasileira de Urologia
dc.relation.ispartof International braz j urol
dc.rights Acesso aberto
dc.subject testosterone en
dc.subject male en
dc.subject deficiency en
dc.subject epidemiological studies en
dc.subject cohort studies en
dc.title Age-related testosterone decline in a Brazilian cohort of healthy military men en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Escola de Saúde do Exército
dc.contributor.institution Brazilian Society of Urology
dc.description.affiliation Federal University of São Paulo Escola de Saúde do Exército
dc.description.affiliation Escola de Saúde do Exército
dc.description.affiliation Brazilian Society of Urology
dc.description.affiliationUnifesp UNIFESP, Escola de Saúde do Exército
dc.identifier.file S1677-55382011000500004.pdf
dc.identifier.scielo S1677-55382011000500004
dc.identifier.doi 10.1590/S1677-55382011000500004
dc.description.source SciELO
dc.identifier.wos WOS:000299854100004



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