Quimioterapia intra-arterial no tratamento do retinoblastoma: experiência de um centro de referência
Data
2022-12-08
Autores
Marques, Márcio Chaves Pedro 
Orientadores
Abdala, Nitamar
Tipo
Tese de doutorado
Título da Revista
ISSN da Revista
Título de Volume
Resumo
Objetivo: descrever as características demográficas e técnicas da nossa série de casos e avaliar a eficácia e a segurança da quimioterapia intra-arterial no tratamento do retinoblastoma nas diferentes vias arteriais de acesso. Métodos: análise retrospectiva de todos os pacientes com retinoblastoma intraocular, submetidos ao tratamento endovascular em um centro de neurorradiologia intervencionista entre janeiro de 2012 e novembro de 2019. Os dados demográficos, os tipos de retinoblastoma, as drogas utilizadas, as vias de acesso arterial, a taxa de enucleação do globo ocular e as complicações perioperatórias foram registrados e compilados. Resultados: foram realizados quinhentos e seis ciclos de quimioterapia intra-arterial em 113 pacientes, totalizando 134 olhos tratados. O cateterismo ostial da artéria oftálmica foi realizado em 370 ciclos (73%) havendo refluxo para a artéria carótida interna em 152 (30%). A taxa de preservação do globo ocular foi de 72%. A taxa de complicação foi de 7,11%. A complicação mais grave foi a ocorrência do reflexo cardiorrespiratório autonômico, presente em 1,97% dos ciclos. Conclusão: nesta série, a quimioterapia intra-arterial para o tratamento do retinoblastoma intraocular mostrou eficácia e segurança nas vias arteriais utilizadas.
Propose: to describe the demographic and technical characteristics of our case series and to evaluate the efficacy and safety of intra-arterial chemotherapy in the treatment of intraocular retinoblastoma in different arterial access routes. Methods: all patients with retinoblastoma who underwent endovascular therapy at an interventional neuroradiology center between January 2012 and November 2019 were retrospectively analyzed. Demographic data, type of retinoblastoma, number of drugs used, catheterization sites, enucleation rate, and perioperative complications were recorded and compiled. Results: five hundred and six cycles of intra-arterial chemotherapy were performed in 113 patients (134 eyes). Ostial catheterization was performed in 370 cycles (73%), with reflux to the internal carotid artery in 152 (30%). The globe preservation rate was 72%. The complication rate was 7.11%. The most severe complication was an autonomic cardiorespiratory reflex reaction, which occurred in 1.97% of cycles. Conclusion: in this series, intra-arterial chemotherapy for the treatment of intraocular retinoblastoma showed efficacy and safety in the arterial routes used.
Propose: to describe the demographic and technical characteristics of our case series and to evaluate the efficacy and safety of intra-arterial chemotherapy in the treatment of intraocular retinoblastoma in different arterial access routes. Methods: all patients with retinoblastoma who underwent endovascular therapy at an interventional neuroradiology center between January 2012 and November 2019 were retrospectively analyzed. Demographic data, type of retinoblastoma, number of drugs used, catheterization sites, enucleation rate, and perioperative complications were recorded and compiled. Results: five hundred and six cycles of intra-arterial chemotherapy were performed in 113 patients (134 eyes). Ostial catheterization was performed in 370 cycles (73%), with reflux to the internal carotid artery in 152 (30%). The globe preservation rate was 72%. The complication rate was 7.11%. The most severe complication was an autonomic cardiorespiratory reflex reaction, which occurred in 1.97% of cycles. Conclusion: in this series, intra-arterial chemotherapy for the treatment of intraocular retinoblastoma showed efficacy and safety in the arterial routes used.