Plakilactone J: Structure and absolute configuration

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Date
2022-11-12
Author
Batista, Andrea Nastri de Luca
Brito, Mateus de Freitas
Batista Junior, João Marcos [UNIFESP]
Valverde, Alessandra Leda
Type
Artigo
Is part of
Tetrahedron Letters
DOI
10.1016/j.tetlet.2022.154241
Metadata
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Abstract
The chemical investigation of the Brazilian marine sponge Plakortis angulospiculatus led to the isolation of the new peroxide-derived polyketide plakilactone J (1). The structure of (-)-1 was established by means of HRMS and NMR analysis, while its absolute configuration was unambiguously determined as (4R,6R) by vibrational circular dichroism spectroscopy and density functional theory calculations.
Keywords
Marine natural products
Polyketides
Stereochemistry
VCD
DFT
Sponsorship
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
URI
https://repositorio.unifesp.br/11600/65921
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