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dc.contributor.authorArida, Ricardo Mario [UNIFESP]
dc.contributor.authorLopim, Glauber Menezes [UNIFESP]
dc.contributor.authorGutierre, Robson Campos [UNIFESP]
dc.contributor.authorSilva, Eduardo Alves da [UNIFESP]
dc.date.accessioned2022-03-07T15:14:13Z
dc.date.available2022-03-07T15:14:13Z
dc.date.issued2020-03
dc.identifier.issn0012-1630pt_BR
dc.identifier.urihttps://repositorio.unifesp.br/xmlui/handle/11600/63390
dc.description.abstractStress during gestation has been shown to affect susceptibility and intensity of seizures in offspring. Environmental stimuli, such as maternal physical exercise, have shown to be beneficial for brain development. Although studies have demonstrated the deleterious influence of stress during pregnancy on seizure manifestation in offspring, very little is known on how to minimize these effects. This study verified whether physical exercise during the pregnancy associated with prenatal stress minimizes seizure susceptibility in offspring at the beginning of postnatal development. Pregnant rats and male pups were divided into the following groups: control, stress, stress/forced exercise, and stress/voluntary exercise. Behavioral manifestations were analyzed after injection of pentylenetetrazol (PTZ; 45 and 60 mg/kg) at ages P15 and P25. Increased behavioral manifestations and seizure severity was observed in the stress group compared with the control group at both ages. At the dose of 45 mg/kg, offspring of stressed mothers who performed both physical exercise models showed an increase in latency for the first manifestation and decrease in the seizures severity at both ages compared with the mothers groups who were only stressed. Prenatal restraint stress potentiated PTZ-induced seizure behavior, and both forced and voluntary exercise during gestation attenuates the negative effects of PTZ-induced offspring.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.format.extent240-249.pt_BR
dc.languageengpt_BR
dc.publisherMichele R. Brumleypt_BR
dc.relation.ispartofDevelopmental Psychobiologypt_BR
dc.rightsAcesso abertopt_BR
dc.subjectEpilepsyen
dc.subjectPentylenetetrazolen
dc.subjectPhysical exerciseen
dc.subjectPrenatal stressen
dc.titlePhysical exercise during pregnancy minimizes PTZ-induced behavioral manifestations in prenatally stressed offspringen
dc.typeArtigopt_BR
dc.description.sponsorshipIDFAPESP 2015/19256‐0 and 2016/08514‐1pt_BR
dc.description.sponsorshipIDCAPESpt_BR
dc.identifier.doi10.1002/dev.21895pt_BR
unifesp.campusEscola Paulista de Medicina (EPM)pt_BR
unifesp.graduateProgramNeurologia-Neurociênciaspt_BR
unifesp.knowledgeAreaNeurociênciaspt_BR
unifesp.researchAreaNeuroplasticidade e exercício físicopt_BR
dc.contributor.authorLatteshttp://lattes.cnpq.br/8352745170435172pt_BR
dc.contributor.authorLatteshttp://lattes.cnpq.br/5026538910540987
dc.contributor.authorLatteshttp://lattes.cnpq.br/3048510516924444
dc.contributor.authorLatteshttp://lattes.cnpq.br/4169664125793140
dc.citation.volume62pt_BR
dc.citation.issue2pt_BR
unifesp.departamentoFisiologiapt_BR


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