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Physical exercise during pregnancy minimizes PTZ-induced behavioral manifestations in prenatally stressed offspring

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Physical exercise during pregnancy minimizes PTZ-induced behavioral manifestations in prenatally stressed offspring.pdf (570.7Kb)
Date
2020-03
Author
Arida, Ricardo Mario [UNIFESP]
Lopim, Glauber Menezes [UNIFESP]
Gutierre, Robson Campos [UNIFESP]
Silva, Eduardo Alves da [UNIFESP]
Type
Artigo
ISSN
0012-1630
Is part of
Developmental Psychobiology
DOI
10.1002/dev.21895
Metadata
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Abstract
Stress during gestation has been shown to affect susceptibility and intensity of seizures in offspring. Environmental stimuli, such as maternal physical exercise, have shown to be beneficial for brain development. Although studies have demonstrated the deleterious influence of stress during pregnancy on seizure manifestation in offspring, very little is known on how to minimize these effects. This study verified whether physical exercise during the pregnancy associated with prenatal stress minimizes seizure susceptibility in offspring at the beginning of postnatal development. Pregnant rats and male pups were divided into the following groups: control, stress, stress/forced exercise, and stress/voluntary exercise. Behavioral manifestations were analyzed after injection of pentylenetetrazol (PTZ; 45 and 60 mg/kg) at ages P15 and P25. Increased behavioral manifestations and seizure severity was observed in the stress group compared with the control group at both ages. At the dose of 45 mg/kg, offspring of stressed mothers who performed both physical exercise models showed an increase in latency for the first manifestation and decrease in the seizures severity at both ages compared with the mothers groups who were only stressed. Prenatal restraint stress potentiated PTZ-induced seizure behavior, and both forced and voluntary exercise during gestation attenuates the negative effects of PTZ-induced offspring.
Keywords
Epilepsy
Pentylenetetrazol
Physical exercise
Prenatal stress
Sponsorship
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
URI
https://repositorio.unifesp.br/xmlui/handle/11600/63390
Collections
  • EPM - Artigos [17701]

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