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dc.contributor.authorBatista, Andrea Nastri de Luca
dc.contributor.authorSantos Junior, Fernando Martins dos
dc.contributor.authorValverde, Alessandra Leda
dc.contributor.authorBatista Junior, João Marcos [UNIFESP]
dc.date.accessioned2021-12-06T11:47:58Z
dc.date.available2021-12-06T11:47:58Z
dc.date.issued2021-12-02
dc.identifierhttps://link.springer.com/article/10.1007%2Fs43450-021-00184-zpt_BR
dc.identifier.urihttps://repositorio.unifesp.br/xmlui/handle/11600/62387
dc.description.abstractThe determination of the absolute configuration of chiral bioactive natural products is a crucial step in their structural characterization. Several well-established techniques, such as X-ray crystallography, stereo-controlled organic synthesis, NMR, and chiroptical spectroscopy, are commonly used to this end. However, even today, the configurational analysis of natural products remains a challenge, with a significant number of reassignments being reported every year. Among chiroptical methods, vibrational circular dichroism (VCD) has emerged as an excellent tool for the assignment of the absolute configuration of structurally diverse chiral natural products directly in solution. This review covers the use of VCD spectroscopy to elucidate the absolute stereochemistry of natural products in Brazil over the last 20 years. Although the number of VCD investigations on secondary metabolites has increased, VCD can still be considered under-explored in Brazil. Therefore, herein, we aim to demonstrate the unparalleled stereochemical discriminatory power of VCD to assign both conformation and absolute configuration of natural products in conditions not commonly accessible to other techniques.pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.languageengpt_BR
dc.publisherSpringerpt_BR
dc.relation.ispartofRevista Brasileira de Farmacognosiapt_BR
dc.rightsAcesso restritopt_BR
dc.subjectAtropoisomerspt_BR
dc.subjectChemical structurept_BR
dc.subjectConformational analysispt_BR
dc.subjectEnantiomerspt_BR
dc.subjectSpecialized metabolitespt_BR
dc.subjectVibrational optical activitypt_BR
dc.titleVibrational circular dichroism for the assignment of absolute configuration of natural products in Brazilpt_BR
dc.typeArtigopt_BR
dc.description.sponsorshipID2019/22319-5pt_BR
dc.description.sponsorshipID431978/2018-2pt_BR
dc.description.sponsorshipID211.319-2019pt_BR
dc.identifier.doi10.1007/s43450-021-00184-zpt_BR
unifesp.campusInstituto de Ciência e Tecnologia (ICT)pt_BR
unifesp.graduateProgramNão se aplicapt_BR
unifesp.knowledgeAreaOutrapt_BR
dc.contributor.authorLatteshttp://lattes.cnpq.br/4209224090500050pt_BR
unifesp.departamentoCiência e Tecnologiapt_BR
unifesp.graduacaoNão se aplicapt_BR


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