Birth weight and its relationship with endothelial function and pattern of endotheliumderived microparticles during childhood: New insight about early vascular damage
Parizotto, Giovanna Pachele [UNIFESP]
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Objectives: To investigate whether a specific endothelium-derived microparticles (EMPs) phenotype could be associated with birth weight and microvascular endothelial function in children. Study design: A total of 95 children, aged 6-14 years, were recruited. Anthropometric measurement, blood pressure, microvascular endothelial function, the biochemical profile was performed. Standardized flow cytometry methods were used to identify and quantify circulating CD144+, CD31+/annexin V+, and CD62E+ EMPs. Results: We found that the circulating number of CD31+/annexin V+ EMPs and CD144+ EMPs EMP levels were correlated with birth weight, systolic blood pressure, microvascular endothelial function, total cholesterol, and LDLc levels. In the multivariable logistic regression models, we identified strong evidence of higher risk of microvascular endothelial dysfunction among children with low birth weight and increased levels of both CD31+/annexin V+ EMPs and LDLc, while low birth weight and elevated LDLc levels have been identified as independent predictors of the high circulating number of both CD31+/annexin V+ and CD144+ > 75th percentile EMPs. Conclusion: our data provide evidence that children who had birth weight at the lowest values showed higher levels of the circulating number of CD31+/annexin V+ and CD144+ EMPs. In addition, the LBW and high levels of both CD31+/annexin V+ and LDLc were significant risk factors for the presence of microvascular endothelial dysfunction.
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