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dc.contributor.authorMoretti, Nilmar Silvio [UNIFESP]
dc.contributor.authorMortara, Renato Arruda [UNIFESP]
dc.contributor.authorSchenkman, Sergio [UNIFESP]
dc.date.accessioned2021-11-29T16:58:13Z
dc.date.available2021-11-29T16:58:13Z
dc.date.issued2021
dc.identifier.urihttps://repositorio.unifesp.br/xmlui/handle/11600/62330
dc.description.abstractTrypanosoma cruzi is the etiological agent of American trypanosomiasis, or Chagas disease, and is transmitted mainly by blood-sucking reduviid insects in endemic countries. Metacyclic trypomastigotes released in the feces during the insect blood meal enter a mammalian host through skin wounds or mucosal membranes and invade sur- rounding cells. After cell invasion, metacyclic trypomastigotes are restrained within a parasitophorous vacuole (PV), from where they escape, transform into amastigotes, and multiply in the cytosol. Later, following binary division, amastigotes differentiate back into highly motile trypomastigotes that are released upon cell lysis. They can infect neighboring cells, migrate to different tissues, or be ingested by an insect vector. The parasites in the tissues, as- sociated with an immune response, contribute to the chronic symptoms of the disease. Reactive oxygen species (ROS), among other factors, play an important role during parasite multiplication and interstage transformation.pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.languageengpt_BR
dc.publisherCell Presspt_BR
dc.relation.ispartofTrends in Parasitologypt_BR
dc.rightsAcesso restritopt_BR
dc.subjectT cruzipt_BR
dc.titleTrypanosoma cruzipt_BR
dc.typeArtigopt_BR
dc.description.sponsorshipIDCNPq: 424729/2018pt_BR
dc.description.sponsorshipIDFAPESP: 2018/09948-0pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.pt.2019.10.002pt_BR
unifesp.campusEscola Paulista de Medicina (EPM)pt_BR
unifesp.graduateProgramMicrobiologia e Imunologiapt_BR
unifesp.knowledgeAreaOutrapt_BR
dc.contributor.authorLatteshttp://lattes.cnpq.br/2131472726202687pt_BR
unifesp.departamentoMicrobiologia, Imunologia e Parasitologiapt_BR


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