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dc.contributor.authorMaran, Suellen Rodrigues [UNIFESP]
dc.contributor.authorFleck, Krista
dc.contributor.authorMonteiro-Teles, Natália Melquie
dc.contributor.authorIsebe, Tony
dc.contributor.authorWalrad, Pegine
dc.contributor.authorJeffers, Victoria
dc.contributor.authorCestari, Igor
dc.contributor.authorVasconcelos, Elton J.R.
dc.contributor.authorMoretti, Nilmar [UNIFESP]
dc.date.accessioned2021-11-29T16:48:26Z
dc.date.available2021-11-29T16:48:26Z
dc.date.issued2021
dc.identifier.urihttps://repositorio.unifesp.br/xmlui/handle/11600/62329
dc.description.abstractProtein lysine acetylation has emerged as a major regulatory post-translational modi!cation in different organisms, present not only on histone proteins affecting chromatin structure and gene expression but also on nonhistone proteins involved in several cellular processes. The same scenario was observed in protozoan para- sites after the description of their acetylomes, indicating that acetylation might regulate crucial biological processes in these parasites. The demonstration that glycolytic enzymes are regulated by acetylation in protozoans shows that this modi!cation might regulate several other processes implicated in parasite survival and adaptation during the life cycle, opening the chance to explore the regulatory acetylation machinery of these parasites as drug targets for new treatment development.pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.languageengpt_BR
dc.publisherCell Presspt_BR
dc.relation.ispartofTrends in Parasitologypt_BR
dc.rightsAcesso restritopt_BR
dc.subjectAcetylationpt_BR
dc.subjectT bruceipt_BR
dc.subjectT cruzipt_BR
dc.subjectMalariapt_BR
dc.titleProtein acetylation in the critical biological processes in protozoan parasitespt_BR
dc.typeArtigopt_BR
dc.description.sponsorshipIDFAPESP: 2018/09948-0pt_BR
dc.description.sponsorshipIDFAPESP: 2019/13765-1pt_BR
dc.description.sponsorshipIDCNPq: 424729/2018pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.pt.2021.04.008pt_BR
unifesp.campusEscola Paulista de Medicina (EPM)pt_BR
unifesp.graduateProgramMicrobiologia e Imunologiapt_BR
unifesp.knowledgeAreaOutrapt_BR
dc.contributor.authorLatteshttp://lattes.cnpq.br/2131472726202687pt_BR
unifesp.departamentoMicrobiologia, Imunologia e Parasitologiapt_BR


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