Raising the Bar(-seq) in Leishmania genetic screens
Ferreira, Tiago R.
Couñago, Rafael M.
Moretti, Nilmar Silvio [UNIFESP]
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Our understanding of regulatory factors in Leishmania differentia- tion has long been restricted by the available genetic tools, but the availability of CRISPR/Cas9 has changed the landscape forever. Recently, Baker and Catta-Preta et al. applied Cas9 editing and kinome-wide bar-seq to dissect the function of 204 kinases in the Leishmania mexicana life cycle.
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