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dc.contributor.authorTeixeira, Samuel Cota
dc.contributor.authorSilva, Marcelo Santos da
dc.contributor.authorGomes, Antoniel Augusto Severo
dc.contributor.authorMoretti, Nilmar Silvio [UNIFESP]
dc.contributor.authorLopes, Daiana Silva
dc.contributor.authorFerro, Eloisa Amália Vieira
dc.contributor.authorRodrigues, Veridiana de Melo
dc.date.accessioned2021-11-29T12:24:05Z
dc.date.available2021-11-29T12:24:05Z
dc.date.issued2021
dc.identifier.urihttps://repositorio.unifesp.br/xmlui/handle/11600/62318
dc.description.abstractParasitic diseases affect millions of individuals worldwide, mainly in low-income regions. There is no cure for most of these diseases, and the treatment relies on drugs that have side effects and lead to drug resistance, emphasizing the urgency to find new treatments. Snake venom has been gaining prominence as a rich source of molecules with antiparasitic potentials, such as phospholipases A2 (PLA2s). Here, we compile the findings involving PLA2s with antiparasitic activities against helminths, Plasmodium, Toxoplasma, and trypanosomatids. We indicate their molecular features, highlighting the possible antiparasitic mechanisms of action of these proteins. We also demonstrate interactions between PLA2s and some parasite membrane components, shedding light on potential targets for drug design that may provide better treatment for the illnesses caused by parasites.pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.languageengpt_BR
dc.publisherCell Presspt_BR
dc.relation.ispartofTrends in Parasitologypt_BR
dc.rightsAcesso restritopt_BR
dc.subjectPLA2pt_BR
dc.subjectLeishmaniapt_BR
dc.titlePanacea within a Pandora's box: the antiparasitic effects of phospholipases A2 (PLA2s) from snake venomspt_BR
dc.typeArtigopt_BR
dc.description.sponsorshipIDCNPq: 424729/2018pt_BR
dc.description.sponsorshipIDFAPESP: 2018/09948-0pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.pt.2021.07.004pt_BR
unifesp.campusEscola Paulista de Medicina (EPM)pt_BR
unifesp.graduateProgramMicrobiologia e Imunologiapt_BR
unifesp.knowledgeAreaOutrapt_BR
dc.contributor.authorLatteshttp://lattes.cnpq.br/2131472726202687pt_BR
unifesp.departamentoMicrobiologia, Imunologia e Parasitologiapt_BR


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